大黄碳酸氢钠片联合莫沙必利治疗2型糖尿病便秘50例临床观察

Clinical observation on 50 cases of constipation in Type 2 diabetes treated with Rhubarb Sodium Bicarbonate Tablets and Mosapride

目的:探讨大黄碳酸氢钠片联合莫沙必利治疗2型糖尿病便秘的临床疗效。方法:选择符合2型糖尿病诊断的150例伴随有食后饱胀、反酸、恶心、厌食、上腹不适、早饱、嗳气、上腹痛、便秘等不同程度的胃轻瘫临床表现患者,随机分为治疗组、大黄碳酸氢钠片组、莫沙必利组3组,每组50例,治疗组用大黄碳酸氢钠片联合枸橼酸莫沙必利,对照组分别选用大黄碳酸氢钠片、莫沙必利治疗,4周为一疗程,四周后观察各组临床症状改善情况及治疗效果。结果:三组治疗4周后患者临床症状均有缓解,排便周期缩短,大便性状改变,尤以治疗组疗效更佳。结论:大黄碳酸氢钠片联合莫沙必利治疗糖尿病便秘疗效显著。

Objective：To investigate the clinical efficacy of Rhubarb Sodium Bicarbonate Tablets combined with Mosapride on constipation in Type 2 diabetes. Methods：150 cases diagnosed as Type 2 diabetes with different clinical gastroparesis manifestations including postprandial fullness, acid regurgitation, nausea, anorexia, abdominal discomfort, early satiety, belching, upper abdominal pain, constipation were randomly divided into a treatment group, a rhubarb Sodium Bicarbonate Tablets group and a mosapride group, 50 cases in each group. The cases in the treatment group were treated with rhubarb Sodium Bicarbonate Tablets combined with mosapride citrate, the cases in the control group respectively with Rhubarb Sodium Bicarbonate Tablets and Mosapride, 4 weeks as a course of treatment. After 4 weeks, the improvement of clinical symptoms and curative effects were observed. Results： After 4 weeks of treatment, the symptoms of patients in the three groups were alleviated, the defecation cycle shortened, the shape of stool changed, especially in the treatment group. Conclusion： rhubarb Sodium Bicarbonate Tablets combined with mosapride has a significant effect on diabetic constipation.