丹参多酚酸盐对早期糖尿病肾病患者血清SOD、MDA的影响

Effect of Salvianolate injection on serum SOD,MDA of Early Diabetic Nephropathy Patients

目的:探讨丹参多酚酸盐对早期糖尿病肾病患者血清SOD、MDA的影响。方法:将血压正常的90例早期糖尿病肾病患者随机分为对照组和治疗组。对照组予以控制血糖、糖尿病教育等常规治疗;治疗组在常规治疗的基础上加用丹参多酚酸盐每日1次,静脉注射,每次100mg,均治疗两周。观察治疗前后两组患者血清SOD、MDA及尿微量白蛋白的变化。结果:经治疗2周后,治疗组患者血清MDA水平及尿微量白蛋白较治疗前明显下降(P<0.01);SOD较治疗前明显升高(P<0.01),且明显优于对照组(P<0.05);结论:丹参多酚酸盐能降低早期糖尿病肾病患者的尿微量白蛋白水平,改善氧化应激,对早期糖尿病肾病具有治疗作用。

Objective： To observe the influence of Salvianolate injection on serum SOD, MDA of Early Diabetic Nephropathy Patients. Methods： Ninety patients whose Blood pressure in the normal range were divided into control group and treatment group. For control group, All of the patients were conventional treatment as blood glucose control, diabetic education and so on. While those in treatment group, besides of treatment as control group, were given Salvianolate injection, 100mg intravenous fluids, 1 time a day. All treatment courses were 2 weeks. The urine trace albumin and the serum SOD, MDA were measured before and after the treatment. Results： After 2 weeks treatment, the level of urine trace albumin and the serum MDA of the treatment groups decreased obviously （P〈0.01）, the serum SOD increased obviously than before （P〈0.01）, Compared with the control group （P〈0.05）. Conclusion： Salvianolate injection had therapeutical effect to Early Diabetic Nephropathy Patients, which can decrease the level of urine trace albumin on early diabetic nephropathy patients, and improve oxidative stress.