8例肾淀粉样变性临床分析

Clinical analysis on 8 cases of renal amyloidosis

目的：探究肾淀粉样变性疾病的临床表现、病理改变及治疗后的转归情况。方法：回顾性分析2011年1月～2014年2月我院接收的8例肾淀粉样变性患者的临床资料，并统计其MP化疗后的转归情况。结果：本研究中8例肾损害患者均表现为肾病综合征，且主要表现为肾小球损害，同时伴有不同程度的血管病变及小管间质病变，通过MP化疗后，病人的生存时间明显延长。结论：肾脏淀粉样变性患者的临床表现多种多样，应依据其病理检查结果急性针对性的治疗，以延长患者的生存时间。

Objective： To investigate the clinical manifestations, pathological changes and the prognosis after treatment of renal amyloidosis. Methods： 8 cases of renal amyloidosis from January,2011 to February, 2014 in our hospital were analyzed and the prognosis after MP chemotherapy was recorded. Results： In this research, 8 patients with renal damage all presented as nephrotic syndrome, manifested as glomerular damage with different degree of vascular lesion and tubulointerstitial lesions. After MP chemotherapy, the survival time of patients was prolonged.Conclusions： The manifestations of renal amyloidosis are various, according to the pathological findings, acute targeted therapy should be taken in order to prolong the survival time of patients.