我院127例地高辛血药浓度监测与结果分析

Analysis of serum concentration monitoring in 127 cases taking digoxin

目的探讨地高辛血药浓度的监测，促进地高辛科学合理用药。方法回顾性分析127例患者地高辛血药浓度的监测结果，观察其疗效。结果地高辛血药浓度〈0．5ng／ml者10例（7．87％），0．5~2．0ng／ml者108例（85．04％），〉2．0ng／ml者9例（7．09％）。结论合理控制地高辛的血药浓度，制订个体化的给药方案，可达到最佳临床治疗效果，有效降低地高辛中毒率，减少药物不良反应的发生。

Objective To investigate and analyze the monitoring of serum digoxin concentration,in order to promote the rational use of digoxin. Methods A retrospective study was conducted to analyze the results of 127 patients＇ serum digoxin concentration,and digoxin＇s effectiveness was observed. Results Serum digoxin concentration less than 0.5 ng/ml were 10 cases accounted for 7.87%;serum digoxin concentration from 0.5 to 2.0 ng/ml were 108 cases accounted for 85.04%;serum digoxin concentration more than 2.0 ng/ml were 9 cases accounted for 7.09%. Conclusion Reasonable control of serum digoxin concentration and individualized dosage regimen can obtain an optimal clinical effect,and also reduce the rate of digoxin toxicity and other adverse reactions.