中枢神经系统白血病患者脑脊液中MMP-2和TNF-α水平变化及意义

Level change of MMP-2 and TNF-α in cerebrospinal fluid of patients with central nervous system leukemia,and its significance

目的探讨中枢神经系统白血病(CNSL)患者脑脊液(CSF)中基质金属蛋白酶-2(MMP-2)和肿瘤坏死因子-α(TNF-α)水平及意义。方法采用酶联免疫吸附试验检测31例CNSL患者(CNSL组)、42例非CNSL患者(非CNSL组)、30例非中枢神经系统疾病和肿瘤的患者(对照组)CSF中MMP-2、TNF-α的水平,并进行比较分析。结果 CNSL组和非CNSL组患者CSF中MMP-2、TNF-α水平均高于对照组,CNSL组患者CSF中MMP-2、TNF-α水平均高于非CNSL组(P<0.05)。结论 CNSL患者CSF中MMP-2、TNF-α明显高表达,两者可能参与了CNSL的发生发展,检测CSF中MMP-2、TNF-α水平有助于CNSL的早期诊断。

Objective To investigate the level change of matrix metalloproteinases-2 （MMP-2） and tumor necrosis factor-α （TNF-α） in cerebrospinal fluid （CSF） of patients with central nervous system leukemia （CNSL） and their significances. Methods Enzyme linked immunosorbent assay was used to detect the levels of MMP-2 and TNF-αof CSF in the 31 patients with CNSL （the CNSL group）, the 42 patients with non-CNSL leukemia （the non-CNSL group）, the 30 patients without central nervous system diseases and neoplasms （as the control group）, and the levels of MMP-2 and TNF-α in above groups were analyzed comparatively. Results The levels of MMP-2 and TNF-α of CSF in the CNSL group and the non-CNSL group were higher than those of the control group, the levels of MMP-2 and TNF-α of CSF in the CNSL group were higher than those of the non-CNSL group （P＆lt;0.05）. Conclusion The high expressions of MMP-2 and TNF-α of CSF are observed in the patients with CNSL, MMP-2 and TNF-α may be involved in the occurrence and development of CNSL,thus detecting the MMP-2 and TNF-α of CSF can be used to early diagnose the CNSL.