上皮间质转化和细胞衰老在肿瘤发生中的共同调节分子

The co-regulatory molecules of epithelial-mesenchymal transition and cellular senescence during tumor development

上皮间质转化(epithelial-mesenchymal transition,EMT)和细胞衰老是与肿瘤发生密切相关的两个重要事件。在肿瘤发展过程中,上皮间质转化是促进迁移和侵袭的重要机制。细胞衰老作为一个重要的细胞自主的肿瘤预防机制,可以抑制细胞转化和肿瘤发生。虽然EMT和细胞衰老发生在肿瘤发展过程中的不同时间段,但众多研究发现,多种介导EMT发生的关键信号通路和转录因子能调节细胞衰老过程;同时,参与细胞衰老的经典信号通路也影响着EMT进程。就联系这两种细胞生物学事件的调控因素作一综述。

The epithelial-mesenchymal transition（EMT） and cellular senescence are two significant cellular processes, which are related to tumorigenesis. EMT is an important mechanism for migration and invasion during tumor development. Cellular senescence functions as a critical cell-autonomous mechanism that can prevent cell transformation and tumorigenesis. Although EMT and cellular senescence occur in the different periods of tumor progression, emerging evidence indicates that numerous EMT-related signaling pathways and transcription factors can regulate cellular senescence. Meanwhile, the classic signaling pathways participating in cellular senescence also affect the EMT process. Here, we discuss the recent advances in the understanding of how these important cellular processes are linked and reciprocally regulated.