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母乳中保护性成分的作用 被引量：12

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摘要 母乳是婴儿营养的生物学模板。乳汁中含有大量生物学活性成分，除为婴儿生长发育提供基本的营养素和能量外，还有保护婴儿抵御感染和炎症以及促进免疫系统成熟、器官发育和正常微生物定植等作用。这种保护性作用目前是难以替代的。由于免疫功能不成熟，以及屏障系统薄弱，新生儿易受病原体感染；在抗原物质刺激后，有过度的炎症反应倾向。母乳中的免疫保护因子可以抵御抗原物质侵害，促进免疫功能成熟，抑制过度炎症反应[1]，保护新生儿逐步适应宫外生长环境。
作者 何振娟
机构地区 上海交通大学医学院附属新华医院新生儿科
出处 《中华围产医学杂志》 CAS 北大核心 2014年第7期441-443,共3页 Chinese Journal of Perinatal Medicine
关键词 生物学活性成分 保护性作用 母乳 过度炎症反应 病原体感染 婴儿生长发育 婴儿营养 免疫系统
分类号 R174 [医药卫生—妇幼卫生保健]
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参考文献16

  • 1Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors[J]. Pediatr Clin North Am,2013,60:49-74.
  • 2Chatterton DE, Nguyen DN, Bering SB, et al. Anti inflammatory mechanisms of bioactive milk proteins in the intestine of newborns[J]. Int J Biochem Cell Biol, 2013, 45:1730-1747.
  • 3Ando K, Hasegawa K, Shindo K, et al. Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling[J]. FEBS J, 2010,277:2051-2066.
  • 4Ichikawa M, Sugita M, Takahashi M, et al. Breast milk macrophages spontaneously produce granulocyte macrophage colony-stimulating factor and differentiate into dendritic cells in the presence of exogenous interleukin-4 alone[J]. Immunology, 2003,108:189-195.
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  • 6Chatterton DE, Nguyen DN, Bering SB, et al. Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns[J]. Int J Biochem Cell Biol, 2013, 45:1730-1747.
  • 7Cavaletto M, Giuffrida MG, Conti A. The proteomic approach to analysis of human milk fat globule membrane[J]. Clin Chim Acta, 2004, 347:41-48.
  • 8Kusunoki R, Ishihara S, Aziz M, et al. Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation[J]. Digestion, 2012, 85:103-107.
  • 9Gao X, McMahon RJ, Woo JG, et al. Temporal changes in milk proteomes reveal developing milk functions[J]. J Proteome Res, 2012, 11:3897-3907.
  • 10Kadaoui KA, Corthesy B. Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer's patches with restriction to mucosal compartment[J]. J Immunol, 2007, 179:7751-7757.

同被引文献109

  • 1许厚琴,金辉,朱丽萍.上海市母乳喂养率及相关因素的调查[J].中国妇幼保健,2005,20(2):183-184. 被引量：29
  • 2陈藜,戴耀华.纯母乳喂养的最佳持续时间的研究进展[J].中国儿童保健杂志,2007,15(6):640-642. 被引量：14
  • 3Zhang S, Li RT, Wang Y, et al. Seroprevalence of hepatitis B surface antigen among pregnant women in Jiangsu, China, 17 years after introduction of hepatitis B vaccine[J]. Int J Gynaecol Obstet, 2010, 109(3):194-197. DOI:10.1016/j.ijgo. 2010.01.002.
  • 4de Oliveira PR, Yamamoto AY, de Souza CB, et al. Hepatitis B viral markers in banked human milk before and after Holder pasteurization[J]. J Clin Virol, 2009, 45(4):281-284. DOI:10. 1016/j.jcv.2009.04.003.
  • 5Yin Y, Wu L, Zhang J, et al. Identification of risk factors associated with immunoprophylaxis failure to prevent the vertical transmission of hepatitis B virus[J]. J Infect, 2013, 66(5):447-452. DOI: 10.1016/j.jinf.2012.12.008.
  • 6Chen X, Chen J, Wen J, et al. Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus[J]. PLoS One, 2013, 8(1):e55303. DOI: 10.1371/journal.pone.0055303.
  • 7Nishimura T, Suzue J, Kaji H. Breastfeeding reduces the severity of respiratory syncytial virus infection among young infants: a multi-center prospective study[J]. Pediatr Int, 2009, 51(6):812-816. DOI: 10.1111/j.1442-200X.2009.02877.x.
  • 8Turin CG, Ochoa TJ. The Role of Maternal Breast Milk in Preventing Infantile Diarrhea in the Developing World. Curr Trop Med Rep, 2014, 1(2):97-105.
  • 9Trend S, Strunk T, Hibbert J, et al. Antimicrobial protein and Peptide concentrations and activity in human breast milk consumed by preterm infants at risk of late-onset neonatal sepsis[J]. PLoS One, 2015, 10(2):e0117038. DOI: 10.1371/journal.pone.0117038.
  • 10Redwan EM, Uversky VN, E1-Fakharany EM, et al. Potential lactoferrin activity against pathogenic viruses. C R Biol, 2014, 337(10):581-595. DOI: 10.1016/j.crvi.2014.08.003. van.

引证文献12

二级引证文献76

中华围产医学杂志
2014年 第7期

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