期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

神经源性尿路障碍兔输尿管功能和L型钙通道表达的变化 被引量：2

原文传递
导出
摘要 神经源性尿路功能障碍（ neurogenic urinary tract dysfunc-tion，NUTD）是指与排尿有关的中枢或外周神经受到损伤后导致的尿路功能障碍，反流性上尿路损害是其重要并发症，与下尿路继发性尿动力学高危因素导致的膀胱内高压状态有关［1］。但是，部分通过治疗使膀胱获得低压储尿和排尿功能的患者，也会发生上尿路损害［2］。最近的研究发现，神经和体液因素均可对输尿管活动有重要调节作用，但NUTD患者输尿管功能的变化及其机制尚不清楚［3］。2012年5月～2012年12月我们通过动物实验对NUTD输尿管功能的变化、病理学改变及L型电压依赖性钙通道（（ L-type voltage-dependent calcium channels ，LVDCC）的表达情况进行了初步研究，以了解NUTD早期上尿路功能的变化及其机制。
作者 王庆伟 苏志强 夏明亮 任川川 郭战 李真珍 宋东奎 文建国 朱庆华
机构地区 郑州大学第一附属医院泌尿外科、河南省小儿尿动力学中心河南省高等学校临床医学重点学科开放实验室 郑州大学护理学院
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2014年第7期557-558,共2页 Chinese Journal of Urology
基金 国家自然科学基金（30901485） 河南省卫生厅科技创新型人才工程“中青年科技创新人才”（4105）
关键词 尿路功能障碍 输尿管功能 L型钙通道 神经源性 电压依赖性钙通道 上尿路损害 排尿功能 病理学改变
分类号 R694.5 [医药卫生—泌尿科学]
  • 相关文献

参考文献10

  • 1Tekgtil S, Riedmiller H, Hoebeke P, et al. European Association of Urology. EAU guidelines on vesicoureteral reflux in children [J]. Eur Urol, 2012, 62: 534-542.
  • 2Wang QW, Wen JG, Song DK, et al. Is it possible to use urody- namic variables to predict upper urinary tract dilatation in chil- dren with neurogenic bladder-sphincter dysfunction? [ J ]. BJU Int, 2006, 98: 1295-1300.
  • 3Yasar A, Erdemir F, Parlaktas BS, et al. The effect of earwdilol on serum and tissue oxidative stress parameters in partial ureteral obstruction induced rat model [ J]. Kaohsiung J Med Sci, 2013, 29: 19-25.
  • 4文建国,苏志强,王庆伟,夏明亮,任川川,郭战,杨超,吕宇涛,张燕莎,张艳.幼兔逼尿肌无收缩模型的建立及影像尿动力学评估[J].中华小儿外科杂志,2013,34(5):373-376. 被引量：3
  • 5王庆伟,文建国,刘会范,等.儿童和青少年神经源性膀胱合并上尿路扩张的尿动力学特点分析[J].中华泌尿外科杂志,2007,10:692-695.
  • 6王智勇,王庆伟,张雪培,魏金星,宋东奎.合并神经原性膀胱活动低下非瘫痪脊髓功能障碍患者生命质量评估和尿动力学研究[J].中华泌尿外科杂志,2010,31(6):405-409. 被引量：3
  • 7Chen Q, Cai J, Shi C, et al. Differences in the development of autogenous nerves between the upper and lower urinary tract [ J ]. Exp Ther Med, 2013, 5: 767-770.
  • 8Berridge MJ. Smooth muscle cell calcium activation mechanisms [J]. J Physiol, 2008, 586: 5047-5061.
  • 9Floyd RV, Borisova L, Bakran A, et al. Morphology, calcium signaling and mechanical activity in human ureter [ J ]. J Urol, 2008, 180: 398-405.
  • 10Balkanci ZD, Pehlivanoglu B, Bayrak S, et al. The effect of hy- percholesterolemia on carbachol-induced contractions of the detru- sot smooth muscle in rats: increased role of L-type Ca2+ channels [ J]. Naunyn Schmiedebergs Arch Pharmacol, 2012, 385 : 1141 - 1148.

二级参考文献28

  • 1滕若冰,梁月有,郑克立,梁卫洁,瞿虎.犬神经原性膀胱模型制作及分析[J].广东医学,2006,27(4):471-472. 被引量：3
  • 2Morton SC,Shekelle PG,Adams JL,et al.Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction.Arch Phys Med Rehabil,2002,83:129-138.
  • 3Ku JH.The management of neurogenic bladder and quality of life in spinal cord injury.BJU Int,2006,98:739-745.
  • 4St(o)hrer M,Blok B,Castro-Diaz D,et al.EAU Guidelines on Neurogenic Lower Urinary Tract Dysfunction.Eur Urol,2009,56:81-88.
  • 5Quek ML,Ginsberg DA.Long-term urodynamics followup of bladder augmentation for neurogenic bladder.J Urol,2003,169:195-198.
  • 6Abrams P,Cardozo L,Fall M,et al.Standardisation SubCommittee of the International Continence Society.The standardisation of terminology in lower urinary tract function,report from the standardisation sub-committee of the International Continence Society.Urology,2003,61:37-49.
  • 7Schafer W,Abrams P,Liao L,et al.Good urodynamic practices:uroflowmetry,filling cystometry,and pressure-flow studies.Neurourol Urodyn,2002,21:261-274.
  • 8Patel AA,Donegan D,Albert T.The 36-item short form.J Am Acad Orthop Surg,2007,15:126-134.
  • 9Reyblat P,Chan KG,Josephson DY,et al.Comparison of extraperitoneal and intraperitoneal augmentation enterocys toplasty for neurogenic bladder in spinal cord injury patients.World J Urol,2009,27:63-68.
  • 10Pannek J,Kullik B.Does optimizing bladder management equal optimizing quality of life? Correlation between health-related quality of life and urodynamic parameters in patients with spinal cord lesions.Urology,2009,74:263-266.

共引文献4

同被引文献29

  • 1赵清,赵克森.钙通道激动剂Bay k 8644对重症失血性休克大鼠细动脉平滑肌细胞膜电位的作用[J].南方医科大学学报,2006,26(4):421-424. 被引量：6
  • 2RobertsMM.Neurophysiology in neurourology[J].Muscle Nerve,2008,38(1):815–836.DOI:10.1002/mus.21001.
  • 3BerridgeMJ.Smooth muscle cell calcium activation mechanisms[J].J Physiol,2008,586(Pt 21):5047–5061.DOI:10.1113/jphysiol.2008.160440.
  • 4ChungYG,SethA,DoyleC,et al.Inosine improves neurogenic detrusor overactivity following spinal cord injury[J].PLoS One,2015,10(11):e141492.DOI:10.1371/journal.pone.0141492.
  • 5RechbergerT,Kulik–RechbergerB,MiotlaP,et al.The new era in the pharmacological treatment of overactive bladder (OAB):mirabegron––a new selective beta3agonist[J].Ginekologia Polska,2014,85(3):214–219.
  • 6WollnerJ,PannekJ.Initial experience with the treatment of neurogenic detrusor overactivity with a new beta–3 agonist (mirabegron) in patients with spinal cord injury[J].Spinal Cord,2016,54(1):78–82.DOI:10.1038/sc.2015.195.
  • 7McKeageK.Propiverine:a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity,and in men with lower urinary tract symptoms[J].Clin Drug Investig,2013,33(1):71–91.DOI:10.1007/s40261–012–0046–9.
  • 8YeJ,WuG,LiX,et al.Millimeter wave treatment inhibits apoptosis of chondrocytes via regulation dynamic equilibrium of intracellular free Ca (2+)[J].Evid Based Complement Alternat Med,2015,2015:464161.DOI:10.1155/2015/464161.
  • 9HristovKL,AfeliSA,ParajuliSP,et al.Neurogenic detrusor overactivity is associated with decreased expression and function of the large conductance voltage–and Ca(2+)–activated K+ channels[J].PLoS One,2013,8(7):e68052.DOI:10.1371/journal.pone.0068052.
  • 10HristovKL,ParajuliSP,SoderRP,et al.Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large conductance Ca2+–activated K+ channels[J].Am J Physiol Cell Physiol,2012,30201):C1632–C1641.DOI:10.1152/ajpcell.00417.2011.

引证文献2

二级引证文献4

中华泌尿外科杂志
2014年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部