中医药治疗慢性肾小球肾炎用药规律及药性系统综述

A Systematic Review Analysis of the Regularity and Property of a Medicine in the Traditional Chinese Medicine Treatment of Chronic Nephritis

[主要目的]分析中医药治疗慢性肾小球肾炎用药规律及药性。[资料来源]维普中文生物医学期刊数据库(CMJD)。[选择文献量及依据]以"中医,慢性肾小球肾炎"为关键词,检索1989年1月至2013年3月维普中文生物医学期刊数据库(CMJD)中医药治疗慢性肾小球肾炎处方用药相关文献。初检文献1386篇,根据文题、摘要,排除重复,剩余209篇查找全文,根据纳入、排除标准,确定纳入108篇,涉及方剂108首,药物189味。[数据提炼规则及应用方法]使用Microsoft Excel2013建立CGN中医用药文献研究数据库,分析有关方药性味、归经、功效。[数据综合得出结果与结论]涉及药物189味,累计频次1185次,频次≥5次60味,累积频率82.11%;频次排序:黄芪(81.80%)>茯苓(55.60%)>丹参(46.30%)>益母草(41.70%);功效类别排序:补虚(35.87%)>活血化瘀(17.16%)>利水渗湿(15.52%)>清热(12.13%)。频次≥5次60味,药性973频次、药味1524频次、归经2502频次;药性排序:温(311)>平(270)>凉(196)>寒(185)>热(11);甘、苦、辛、淡四味计1354频次(87.81%);主归肝、脾、肾、肺、心、胃诸经,计2080频次(83.13%)。临床常以黄芪、茯苓、丹参与益母草为基础方,用药补虚为首,配伍活血化瘀、利水渗湿与清热药,提示CGN病理特点为本虚标实,寒热错杂,瘀湿互结。[未来展望]治疗慢性肾炎重在补气健脾,活血泄浊。

[Objective] To analyze the regularity and property of a medicine in the traditional Chinese medicine treatment of chronic nephritis. [Sources] VIP Chinese biomedical journals database（CMJD）. [Select literature and Baisi] Used Chinese medicine and chronic glomerulonephritis as keywords to search VIP Chinese biomedical journals database（CMJD）in 1989 January to 2013 March. With 1386 articles detected early,there are 209 articles after eclude the repetitive according to the title and abstract. Then according to inclusion and exclusion criteria,108 articles were determined,involving 108 formula,189 kinds of herbs. [Data refinement rules and Application methods] Used Microsoft Excel 2013 to establish CGN Chinese medicine literature database,analyze the related parties,tropism,efficacy of drug. [Data integration results and conclusions] Relates to 189 kinds of herbs,1185 cumulative times;60 herbs：times≥5,82.11% cumulative times;high frequency of drug ordering：Huang Qi（81.80%） Poria Cocos（55.60%） Radix Salviae Miltiorrhizae（46.30%） Motherwort（41.70%）;function category sequence：tonifying（35.87%） Huoxuehuayu（17.16%） dampness and diuresis（15.52%） antipyretics（12.13%）. The Statistical of 60 herbs（times≥5）about effect,nature and flavor,channel tropism：property of Chinese herbal medicine 973 times,flavour of a drug 1524 times,channel tropism 2502 times;nature and flavor sequence：warm（311） neutral（270） cold（196） colder（185） heat（11）;four kinds of flavour of a drug（sweet,bitter,pungent,light）1354 times,accounted for 87.81%;the main channel tropism：liver,spleen,kidney,lung,heart,stomach,a total of 2080 times,accounting for 83.13%. Astragalus,Poria cocos,Salvia miltiorrhiza and motherwort as basic medicines in clinical,tonifying drug as the mainly prescription,and mainly combined with Huoxuehuayu drugs,dampness and diuresis drugs and antipyretics,pathological features of CGN is that asthenia in origin and asthenia in superficiality,intermingled cold and heat,damp-stasis accumulationin. [Future Prospects] the statistical analysis results can provide the scientific evidence for clinical medication in treatment of chronic nephritis,focusing on the spleen qi,Huoxue Xiezhuo,and screening out effective drug for clinical reference,provide the basis for the preparation of traditional Chinese medicine.