植物化学成分、益生菌和脂肪酸对炎症性肠病的治疗作用

Therapeutic Effects of Phytochemicals,Probiotics and Fatty Acids on Inflammatory Bowel Disease

炎症性肠病(IBD)是一种慢性非特异性肠道炎症性疾病,近年其发病率在全亚洲范围内呈快速上升趋势,饮食结构的改变如高饱和脂肪、低果蔬饮食可能与其发病率升高有关。研究发现一些天然产物如植物化学成分、益生菌、膳食纤维、脂类等具有抗IBD作用,但确切机制不明。本文对植物化学成分、益生菌和脂肪酸对IBD的治疗作用及其可能机制作一综述。

Inflammatory bowel disease （IBD） is a chronic, non-specific inflammatory disease of the intestinal tract. The incidence of IBD increased rapidly in recent decades in Asia, and the increase may be associated with the high dietary intake of saturated fat and low intake of fruits and vegetables. It was reported that some natural products, including phytochemicals, probiotics, dietary fibers and lipids, had anti-IBD effects. However, the exact mechanism is still unclear. The therapeutic effects of phytochemicals, probiotics and fatty acids on IBD and its potential mechanisms were reviewed in this article.