鲍曼不动杆菌耐药机制及治疗策略研究进展

Recent advances in resistance mechanisms of Acinetobacter baumannii and treatment strategies

鲍曼不动杆菌具有强大的获得耐药性和克隆传播的能力,对多种抗生素的耐药机制非常复杂。多重耐药、泛耐药鲍曼不动杆菌呈世界性流行,已成为我国院内感染最重要的病原菌之一,为院内感染治疗提出了新的挑战。因此,明确鲍曼不动杆菌的耐药机制并制定有效的治疗策略有重要的意义。本文对鲍曼不动杆菌耐药机制和治疗策略的最新进展进行综述。

Acinetobacter baumannii has the potent abilities of acquiring drug resistance and clonal propagation, and the mechanisms of resistance to multiple antibiotics are very complex. Multidrugresistant and pandrugresistant Acinetobacter baumannii are prevalent worldwide and in China Acinetobacter baumannii has become one of the most important pathogens that cause nosocomial infections, which has posed new challenges for the treatment of nosocomial infections. So it is of great importance to recognize the resistance mechanisms and formulate effective treatment strategies. This article gives an overview of the recent advances in the resistance mechanisms of Acinetobacter baumannii and treatment strategies to combat Acinetobacter baumannii infections.