归脾汤治疗心脾两虚型抑郁症

Clinical Research of Guipi Decoction as Treatment for Heart-Spleen Deficiency Depression

目的观察归脾汤对于心脾两虚型抑郁症患者的疗效。方法将60例心脾两虚型抑郁症患者随机分为观察组和对照组,各30例。观察组口服归脾汤加减,对照组口服氟西汀。疗程均为6周。在治疗的第1,2,4及6周时,采用汉密顿(hamilton depression scale,HAMD)量表、中医症状量表及社会功能缺陷筛选量表(social disability screening schedule,SDSS)评价2组疗效,并记录不良反应。结果 2组的中医症状疗效有效率随治疗时间不断提高。在治疗后第1,2周时,观察组总有效率高于对照组(P<0.01),在治疗后第4,6周时2组的总有效率差异无统计学意义。2组治疗后不同抑郁程度患者构成比例与治疗前相比均有统计学意义(P<0.01)。2组相比,治疗前后不同抑郁程度患者构成比例无统计学意义。治疗后第1,2,4,6周2组SDSS评分均无统计学意义,观察组不良反应发生率低于对照组(P<0.01)。结论归脾汤可显著改善心脾两虚型抑郁症患者的中医症状和社会功能,使多数患者治愈或转为阈下抑郁。与氟西汀疗效相当,但比氟西汀不良反应少,起效早。

Objective To investigate the clinical therapeutic effects of Guipi decoction for Heart-Spleen deficiency depres- sion. Method Sixty cases were randomly divided into observation group and control group （ n = 30 each）. In observation group GuiPi decoction was given to the patients and in control group Fluoxetine was given. The treatment course continued 6 weeks. Hamilton rating scale for depression （HAMD）, Traditional Chinese medicine （TCM） syndrome manifestations and So- cial disability screening schedule（SDSS） were measured to evaluate therapeutic effects on the lst,2 nd,4 th and 6th week. Record the adverse reactions. Result The efficacy rate of TCM syndrome increased in both groups along with treatment time. On the 1 st and the 2 nd week, the efficacy rate of observation group is higher than control group too（ P 〈 0. O! ）. There was no significant difference between the two groups on the 4th and 6th week. There was significant difference between be- fore and after treatment in the proportion of patients with different degrees of depression in both groups （ P 〈 0.01 ）. There was no significant difference between the two groups in the proportion of patients with different degrees of depression. And there was no significant difference between the two groups in scores of SDSS on the 1 st, 2 nd, 4 th and 6 th week. The rate of adverse reactions in GuiPi decoction group was lower than control group （ P 〈 0.01 ）. Conclusion Guipi decoction can significantly improve the TCM syndrome and social function of Heart-Spleen deficiency depression patients. The majority of the patients were cured or turned into subliminal depression after treatment by Guipi decoction. It＇s clinical therapeutic ef- fects is as good as Fluoxetine, but it has fewer adverse reactions and faster onset of action. So Guipi decoction is a safe and effective treatment for Heart-Spleen deficiency depression.