胎膜早破与解脲支原体、沙眼衣原体感染及妊娠结局关系

RELATIONSHIP BETWEEN UREAPLASMA UREALYTIVUM CHLAMYDIA TRACHOMATIS INFECTION AND PREMATURE PUPTURE OF MEMBRANE AND PREGNANCY OUTCOME

目的：探讨胎膜早破与宫内解脲支原体、沙眼衣原体感染及妊娠结局的关系，为胎膜早破的预防和治疗提供理论依据。方法：选取2012-10～2013-10期间在我院分娩的并有完整随访资料50例胎膜早破孕妇作为实验组，随机选取同时期50例在本院住院分娩无胎膜早破孕妇作为对照组。同时运用荧光定量PCR技术检测其宫颈分泌物解脲脲支原体、衣原体感染率。结果：50例胎膜早破孕妇中，解脲支原体感染率达58％，与胎膜未破孕妇相比较，差异有统计学意义（ P＜0.05）；UU-DNA预测胎膜早破感染敏感度较高，但是特异度和准确性要低于CT-DNA；同时胎膜早破合并宫内感染的孕妇与未感染的孕妇相比，早产、产褥感染、新生儿肺炎的发生率增加，差异有统计学意义（P＜0.05）。结论：胎膜早破与解脲支原体感染密切相关，其对母儿预后造成严重威胁。应加强孕期保健，积极预防与及时诊治宫内感染以改善母儿预后。

Objective：To evaluate the relationship between Ureaplasma urealyticum and chlamydia trachomatis infections and Pre -mature Rupture of Membranes （ PROM） and pregnancy outcomes in order to provide effective methods for clinical prevention and treat -ment of pregnancy complications .Methods：Collecting 50 cases of PROM pregnant women in our hospital from October 2012 to October 2013 as research objects .Meanwhile, the control group was randomly selected from the 50 cases in the same period in our hospital childbirth without PROM pregnant women .The FQ-PCR technique was used to detect the cervical secretions of Ureaplasma urealytic -um and chlamydia trachomatis infection rate .Results：In the 50 cases of pregnant women with premature rupture of membranes , the in-fection rate of Ureaplasma urealyticum was 58%.Compared with the normal pregnant women , the difference was statistically significant （P〈0.05）.The UU-DNA levels predicting premature rupture of membranes expressed higher sensitivity , but the specificity and ac-curacy were lower than CT -DNA.PROM and combined intrauterine infection of pregnant women compared with uninfected pregnant women had an increased incidence of premature birth , puerperal infection , neonatal pneumonia .The difference was statistically signifi-cant （P〈0.05）.Conclusion：PROM is closely related to Ureaplasma urealyticum infection , which poses a serious threat to maternal-fetal outcomes .Prenatal care should be strengthened , positives prevention , timely diagnosis and treatment of intrauterine infection have to be provided in order to improve the prognosis of maternal -fetal.