39例乳腺癌并肝转移诊治体会

Diagnosis and treatment of 39 cases of breast cancer patients with liver metastases

目的:总结乳腺癌并肝转移的临床诊断及治疗特点。方法:回顾性分析2008年1月到2013年8月期间西安交通大学医学院第二附属医院收治的39例乳腺癌并肝转移患者的临床详细资料。结果:本文对39例乳腺癌并肝转移患者进行分析,随访3年余,生存27例,死亡12例,均死于肿瘤进展,中位疾病进展时间(PFS)为25个月,中位随访时间(MSR)为17个月,诊治过程中肿瘤反反复复,呈难治、多药耐药倾向。结论:乳腺癌并肝转移预后差,治疗棘手,关键在于早期发现、早期诊治。对于HER-2阳性患者,赫塞汀靶向治疗是一个有效的治疗选择;对于疗效较好的患者,维持治疗是非常必要的。通过积极综合治疗,可以延长生存期,提高生活质量。

Objective：To summary clinical diagnosis, treatment characteristics of breast cancer with liver metasta- sis. Methods： Retrospective analysis was performed on 39 cases of breast cancer with liver metastases. Results： All 39 cases of breast cancer patients with liver metastases were analyzed and followed up for more than 3 years, survival in 27 cases, 12 dead, died of tumor progression. Median PFS was 25 months, with a median survival of 17 months. Con- clusion：Breast cancer with liver metastasis has poor prognosis, difficult treatment, the key is early diagnosis and treat- ment. Active integrated treatment can prolong survival and improve life quality.