摘要
目的:观察卡培他滨维持治疗转移性乳腺癌的疗效和毒副反应。方法:2009年10月-2013年7月,31例转移性乳腺癌一线或二线含卡培他滨联合化疗4-6个周期后,疾病达缓解或稳定的患者,接受卡培他滨维持治疗,卡培他滨1000mg/m2,d1-14,休息7天,21天为1个周期,维持化疗进展或不能耐受毒副反应者化疗停止,每个患者接受至少2个周期维持治疗。结果:卡培他滨维持治疗转移性乳腺癌有效率(RR)为6.5%,临床获益率(CBR)(>6个月)为35.5%,疾病控制率(DCR)为74.2%,中位无进展生存期(PFS)为5.8个月。主要的毒副反应为手足综合征(HFS),发生率为67.7%,多为Ⅰ-Ⅱ度,1例Ⅲ度患者应用大剂量维生素B6且卡培他滨减量后好转。Ⅲ-Ⅳ度白细胞、中性粒细胞下降分别为9.7%和12.9%,明显低于卡培他滨联合化疗时Ⅲ-Ⅳ度白细胞、中性粒细胞下降发生率的35.5%和38.7%(P<0.05)。结论:卡培他滨是维持治疗转移性乳腺癌的有效药物,患者耐受性好,毒副反应较轻。
Objective:To obsere the effect and adverse reaction of capecitabine maintain treating metastatic breast cancer. Methods:During October 2009 to July 2013,31 cases of metastatic breast cancer patients were given the maintain treatment of capecitabine patients were given capecitabine 1000mg/m2, d1-14, rest 7 days. 21 days as 1 cy- cle,at least two cycles maintenance. Results:RR was 6.5% ,clinical benefit rate(CBR) ( 〉 6 months) was 35.5% , disease control rates(DCR) was 74.2%. The median progression- free surial(PFS) was 5.8 months. The main ad- verse reactions was hand -foot syndrome(HFS) incidence was 67.7% ,most were I - Ⅱ degrees, 1 case was Ⅲ de- gree. Ⅲ - IV degree white blood cells fell by 9.7 %, neutrophils fell by 12.9%, which were significantly lower than that of capecitabine chemotherapy in which the incidence rate were 35.5% and 38.7% (P 〈 0.05 ). Conclusion: Capecitabine is effective on treating metastatic breast cancer. The adverse reaction is light.
出处
《现代肿瘤医学》
CAS
2014年第7期1599-1601,共3页
Journal of Modern Oncology
关键词
卡培他滨
转移性乳腺癌
维持治疗
capecitabine
metastatic breast cancer
maintenance therapy