摘要
Traumatic brain injury （TBI） and spinal cord injury （SCI） causes significant cell death （Raghupathi et al., 1995; DeKosky et al., 1998; Hall et al., 2005; Farkas and Povlishock, 2007） and tissue lesion in the neocortex （Lighthall et al., 1989; Lyeth et al., 1990）, leaving many patients with substantial motor dis- ability and cognitive impairment （Harem et al., 1992; Scheff et al., 1997）. Unfortunately, at present, there are no clinically demonstrated FDA approved drug therapies for treatment of TBI and SCI patients that reduce the neurological injuries. Thus, TBI and SCI are serious health problems. The devel- opment of therapeutic approaches to prevent neuronal death and enhance neuroregeneration for promoting post-traumat- ic functional recovery would be of enormous clinical, social, and economic benefits. The reviews in this specific issue focus largely on the current progress on diagnosis, neuroprotection, and potential neurorepair with stem cells.
Traumatic brain injury （TBI） and spinal cord injury （SCI） causes significant cell death （Raghupathi et al., 1995; DeKosky et al., 1998; Hall et al., 2005; Farkas and Povlishock, 2007） and tissue lesion in the neocortex （Lighthall et al., 1989; Lyeth et al., 1990）, leaving many patients with substantial motor dis- ability and cognitive impairment （Harem et al., 1992; Scheff et al., 1997）. Unfortunately, at present, there are no clinically demonstrated FDA approved drug therapies for treatment of TBI and SCI patients that reduce the neurological injuries. Thus, TBI and SCI are serious health problems. The devel- opment of therapeutic approaches to prevent neuronal death and enhance neuroregeneration for promoting post-traumat- ic functional recovery would be of enormous clinical, social, and economic benefits. The reviews in this specific issue focus largely on the current progress on diagnosis, neuroprotection, and potential neurorepair with stem cells.
