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神经调节蛋白1-ErbB信号通路的研究进展 被引量：15

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摘要 神经调节蛋白（neuregulin,NRG）在细胞的生存,迁移以及分化中扮演着重要的角色,它通过激活称为ErbBs蛋白的受体酪氨酸激酶（表皮生长因子受体的经典成员）进行一系列的信号转导.有四种ErbB受体：EGFR（ErbB 1/HER1）,ErbB2（neu/HER2）,ErbB3/HER3,和ErbB4/HER4..神经调节蛋白通过编码基因不同分为神经调节蛋白1-4：NRG1,NRG2,NRG3,和NRG4[1].其中NRG1已经得到大量研究,而NRG2,NRG3,NGR4的功能研究甚少.NRG1-ErbB信号通路在神经发育,细胞增殖分化等生命过程中发挥着重要作用,与精神分裂症等神经发育异常所导致的疾病以及癌症,心力衰竭,心肌梗死等疾病的发生发展密切相关.NRG1-ErbB信号通路机制的更广泛研究将有助于为大量的临床疾病提供有效的治疗措施,现就近几年来对NRG1-ErbB信号通路的最新研究进展作一综述.
作者 郭汝金 敖丽娟 李咏梅 陈茉弦
机构地区 昆明医科大学第二附属医院康复医学科
出处 《中国康复医学杂志》 CAS CSCD 北大核心 2014年第7期679-684,共6页 Chinese Journal of Rehabilitation Medicine
基金 云南省科技厅计划项目(2010NS)
关键词 神经调节蛋白 信号通路机制 细胞增殖分化 表皮生长因子受体 ErbB受体 神经发育异常 受体酪氨酸激酶 临床疾病
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献7

  • 1Jian Xiao,Bingong Li,Zeqi Zheng,Menghong Wang,Jingtian Peng,Yong Li,Zhe Li.Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction[J].Coronary Artery Disease.2012(7)
  • 2Ryuichi Matsukawa,Yoshitaka Hirooka,Masaaki Nishihara,Koji Ito,Kenji Sunagawa.Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system[J].Journal of Hypertension.2011(9)
  • 3Bingzhang Jie,Xiaoxia Zhang,Xuesi Wu,Yi Xin,Yong Liu,Yongfang Guo.Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore[J].Molecular and Cellular Biochemistry.2012(1)
  • 4Bernd Ebner,Stefan A. Lange,Thomas Eckert,Clementine Wischniowski,Annette Ebner,Rüdiger C. Braun-Dullaeus,Christof Weinbrenner,Carsten Wunderlich,Gregor Simonis,Ruth H. Strasser.Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction[J].Molecular and Cellular Biochemistry.2013(1)
  • 5Pedro Mendes-Ferreira,Gilles W. De Keulenaer,Adelino F. Leite-Moreira,Carmen Brás-Silva.Therapeutic potential of neuregulin-1 in cardiovascular disease[J].Drug Discovery Today.2013
  • 6唐彬秩,屈艺,母得志.神经调节蛋白1在神经发育中的研究进展[J].神经解剖学杂志,2009,25(3):357-360. 被引量：2
  • 7Wei-Jiang Zhao,Melitta Schachner.Neuregulin 1 Enhances Cell Adhesion Molecule L1 Expression in Human Glioma Cells and Promotes Their Migration as a Function of Malignancy[J].Journal of Neuropathology & Experimental Neurology.2013(3)

二级参考文献19

  • 1Tan W, Wang Y, Gold Bet al. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 ( NRGI ) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem, 2007 ;282:24343 - 24351
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  • 6Ozaki M, Itoh K, Miyakawa Yet al. Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner. J Neurochem, 2004 ;91 : 176 - 188
  • 7Bublil EM, Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol, 2007 ; 19:124 - 134
  • 8Liu Y, Tao YM, Woo RS et al. Stimulated ErbB4 internalization is necessary for neuregulin signahng in neurons. Biochem Biophys Res Commun, 2007 ;354:505 - 510
  • 9Bjarnadottir M, Misner DL, Havenqeld-Gross Set al. Neuregulin 1 ( NRG1 ) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1^+/- knock-outs compared with wild-type mice. J Neurosci, 2007 ;27:4519 -4529
  • 10Sardi SP, Murtie J, Koirala Set al. Presenilin-dependent ErbB4- nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell, 2006 ; 127 : 1 85 - 197

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中国康复医学杂志
2014年 第7期

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