多囊卵巢综合征患者子宫内膜容受性的特点

Uterine Receptivity in Women with Polycystic Ovary Syndrome

有生育障碍的多囊卵巢综合征(PCOS)患者子宫内膜容受性受损是近年来生殖领域研究的热点,研究发现子宫内膜的厚度、容积及内膜下血流的减少,子宫内膜间质的异常、性激素及其受体的不均衡表达,以及子宫内膜容受性标志物的降低等均可导致子宫内膜容受性受损。本文将多囊卵巢综合征患者的子宫内膜容受性特点从超声影像学、病理组织学特点、性激素受体及着床期分子表达、基因芯片、转录组学等五个方面来阐述。

The research of endometrial receptivity damaged in women with polycystic ovary syndrome （PCOS）, whose fertility was impaired, has become a hot pot in the area of reproduction. Researchs had indicated the reduction of endometrial thickness, volume and the endometrial blood flows, the abnormality of endometrial stromal, the imbalances expression of sex hormone and its receptors, and the decrease of endometrial receptivity markers can result in a reduction of endometrial receptivity. All above will be analyzed in five aspects in this article, such as ultrasound image, histopathology, sex hormone receptor and molcular expression at implantation phase, gene chip and transcriptomics.