摘要
在胚胎种植过程中,需要促炎因子与抗炎因子相互平衡,才能保证成功妊娠的建立与维持。子宫内膜炎或亚临床子宫内膜感染破坏了各因子之间的平衡状态,形成具有细胞和胚胎毒性的子宫内膜微环境,不利于精子成活和胚胎着床;引起炎症的病原体还可激发机体的免疫反应,产生大量致敏的活性细胞及多种细胞因子、炎性细胞,杀灭和吞噬精子;免疫抗体可干扰正常胚胎和内膜间的组织相容性,影响胚胎着床和胚胎发育;导致胚胎种植失败、自然流产、早产等不良妊娠结局。临床上应给予重视并积极治疗,以提高IVF-ET的妊娠率。
In the process of embryo implantation, hormones, nervus, immune, genes and cytokines play roles together and ultimately achieve the synchronous development between embryo and endometrium. It needs a balance state of cytokines between pro-inflammatory and anti-inflammatory in this process of the establishment and maintenance for the successful pregnancy. Endometrial inflammatory exudative changes may undermine the balance among the factors, and cause a toxic endometrial microenvironment which is harmful to embryo implantation and assisted reproductive outcomes, so we need pay enough attention in order to improve the IVF-ET pregnancy rates.
出处
《生殖与避孕》
CAS
CSCD
2014年第7期580-583,598,共5页
Reproduction and Contraception
关键词
子宫内膜容受性
体外受精
胚胎种植
炎性因子
endometrial receptivity
in vitro fertilization （IVF）
embryo transfer （ET）
inflammatory factors
