摘要
慢性肾病(CKD)患者的血液钙、磷、甲状旁腺激素、维生素D、成纤维细胞生长因子-23等生化因子的水平会发生异常,这不仅能导致长期的系统性并发症,还会引起骨矿物质代谢失衡,造成骨损伤,增加慢性肾病合并矿物质与骨代谢紊乱(CKD-MBD)的患病率和死亡率。本文对CKD-MBD的发病机制、临床诊断与治疗策略作一综述。
The abnormal levels of calcium, phosphorus, parathyroid hormone, vitamin D, fibroblast growth factor-23 in the blood of patients with chronic kidney disease （CKD） will not only cause long-term systematic complications, but also lead to bone mineral metabolism imbalance and bone injury, and finally increase the risk of morbidity and mortality with CKD-MBD. In this review, we summarize the pathogenesis, clinical diagnosis and treatment strategy for CKD-MBD.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2014年第6期695-700,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
上海市科学技术委员会资助(10PJ1407700)
