KIF14过表达与肝细胞肝癌的发生密切相关

KIF14 EXPRESSION CLOSELY RELATED WITH HEPATOCELLULAR CARCINOMA TUMORIGENESIS

目的探讨KIF14表达与肝细胞肝癌发生的关系。方法应用实时荧光定量聚合酶链反应检测50例肝细胞肝癌组织及50例正常肝组织中KIF14的表达。结果与正常肝组织相比,KIF14 mRNA在肝细胞肝癌组织中过表达(P<0.01)。肝细胞肝癌中KIE14 DNA拷贝数也明显高于正常肝组织(P<0.01)。结论 KIF14.过表达在肝细胞肝癌的发生过程中发挥着重要作用,它也许可以作为肝癌的潜在治疗靶点。

Objective To investigate the relationship between KIF14 expression and hepatocellular carcinoma（ HCC ）. Methods This study explored the correlation between KIF14 expression and hepatocellular carcinoma by determining KIF14 expression in HCC tissues and normal liver tissues. Real-time quantitative polymerase chain reaction was applied to test KIF14 in 50 cases of HCC tissues and 50 cases of normal liver tissues. Results Compared with the normal liver tissues,KIF14 mRNA in HCC tissues was overexpressed（ P ﹤0 . 01 ）. KIF14 DNA copies in HCC tissues were also significantly higher than those in normal liver tissues（ P﹤0. 01 ）. Conclusion KIF14 overexpression is very important in HCC tumorigenesis and may serve as a potential therapeutic target for HCC.