他达拉非治疗骨盆骨折尿道损伤后勃起功能障碍的临床观察

Efficacy of Tadalafil in treating erectile dysfunction induced by pelvic fracture urethral injury

目的:观察他达拉非对骨盆骨折尿道损伤后勃起功能障碍患者勃起功能的疗效,对其有效性进行临床观察。方法:对患者进行病史询问、泌尿生殖系统查体、激素内分泌检查、勃起功能障碍国际指数-5评分(IIEF-5评分)、阴茎夜间勃起试验(NPT)、阴茎血流多普勒超声检查等方法,对骨盆骨折合并尿道损伤引起的勃起功能障碍患者28例进行诊断、分类,随机分为实验组和对照组,对照组(14例)在常规治疗基础上加用安慰剂,实验组(14例)在常规治疗基础上加用他达拉非,治疗前均进行心理辅导,共观察12周。比较治疗前后IIEF-5评分,以评价其临床疗效。结果:实验组患者IIEF-5评分明显优于对照组。结论:他达拉非对男性骨盆骨折尿道损伤后勃起功能有良好的恢复和治疗作用,临床治疗中可以积极应用。

Objectives： To observe the curative effect of Tadalafil on patients with erectile dysfunction （ED） induced by pelvic fracture urethral injury （PFUI） to evaluate the efficacy. Methods： Twenty -eight patients with PFUI - induced ED were diagnosed, classified and randomly divided into experimental group and control group through history taking, physical examination on urogenital system, hormone incretion examination, International Index of Erectile Function -5 （IIEF- 5 ） scoring, nocturnal erection of penis test （NPT）, penile hemodynamics with Doppler ultrasonography and etc. The control group received conventional treatment and placebos while experimental group were given conventional treatment and Tadalfil. Both groups were given psychological rehabilitation before the treatment. IIEF -5 scores were compared before and after the treatment to evaluate the clinical curative effect after 12 weeks＇ observation. Results： The IIEF-5 scores in experimental group were significantly higher than those in control group. Conclusion： Tadalafil can effectively improve the erectile function of PFUI - induced ED patients, which could be widely used in clinic.