糖化血红蛋白与糖尿病视网膜病变黄斑区厚度的关系

Research the Relations between HbA1C and the Thickness of Diabetic Retinopathy in the Macular Area

目的：研究早期糖尿病视网膜病变患者黄斑区视网膜厚度与相关生化指标糖化血红蛋白（HbA1C）的关系。方法：糖尿病组20 例40 眼，男12 例，女8 例；糖尿病病程为5～10 年；对照组20 例40 眼，男14 例，女6 例，应用光学相干断层扫描（OCT）测量黄斑区视网膜厚度，应用相关生化仪检测糖尿病组的糖化血红蛋白比（HbA1C）。比较两组黄斑区视网膜的厚度，包括黄斑中央厚度（CPT），黄斑中心凹下厚度（SCMT）,黄斑容积（TMV），分析糖尿病组黄斑区厚度与相关生化指标的HbA1C 关系。结果：糖尿病组所选患者黄斑区厚度比正常组大t=4.0772 （P＜0.01），黄斑区视网膜厚度与糖化血红蛋白（HbA1C）比呈正相关t=3.927（P＜0.05）。结论：对于糖尿病视网膜病变的患者，检测糖化血红蛋白（HbA1C）变化，有利于预测早期糖尿病视网膜病变并发症的发生。

Objective： To research the relationship of retinal thickness at macular area and related biochemical indicators HbA1C in early diabetic retinopathy patients. Methods： Diabetes group had 20 cases （40 eyes）, male is 12 cases and female is 8 cases. The control group had 20 cases （40 eyes）, male is 14 cases and female is 6 cases, optical coherence tomography （OCT） was applied to measuring the retinal thickness at macular area. including central macular thickness（CPT）, thickness ofmacular central concave down （SCMT）, macular volume （TMV）. Related biochemical analyzer was used to test glycosylated hemoglobin （HbA1C） in the diabetes group. Two groups of retinal thickness at macular area were compared and the relationship of macular area thickness and related biochemical indicators in the diabetes group was analyzed. Results： Macular area in the selected diabetes group patients was thicker than that in normal group, which was positively correlated with HbA1C （P〈0.05）. Conclusion： For patients with early diabetes, detecting the macular area thickness and HbA1C changes is conductive to the early prediction of complications of diabetes.