维、汉民族H型高血压血清同型半胱氨酸浓度的调查研究

The Uigur and Han Nationality H Type Hypertension for Serum Homocysteine Concentration of Research

目的:探讨维、汉民族H型高血压血清Hcy浓度差异。方法:用横断面调查的方法收集2011年6月-2012年12月新疆医科大学第五附属医院住院587例H型高血压患者进行调查,资料收集包括民族、高血压分级、血清Hcy。共收集汉族305例(男:203例;女102例),其中高血压Ⅰ级、Ⅱ级、Ⅲ级分别为176例、85例、44例;收集维族282例(男:187例;女:95例),其中高血压Ⅰ级、Ⅱ级、Ⅲ级分别为157例、71例、54例;以高效液相色谱法测定血清Hcy水平,分别以维、汉民族间性别及高血压分级进行统计学分析。结果:维族男性血清Hcy水平(16.30±9.97μmol/L)明显高于汉族男性(13.12±7.43μmol/L)(P<0.05),维族女性血清Hcy水平(14.91±9.62μmol/L)明显高于汉族女性(11.12±8.43μmol/L)(P<0.05);维族高血压Ⅰ级血清Hcy水平(11.40±5.97μmol/L)与汉族高血压Ⅰ级血清Hcy水平(11.36±4.27μmol/L)相当(P>0.05),维族高血压Ⅱ、Ⅲ级血清Hcy水平(16.55±6.69、28.87±9.12μmol/L)均高于汉族高血压Ⅱ、Ⅲ级血清Hcy水平(14.45±5.61、22.36±10.15μmol/L)(P<0.05)。结论:维、汉民族H型高血压血清Hcy浓度可能有一定差异,且维族高于汉族。

Objective： In order to investigate difference between Hcy concentration in serum of type H hypertension patients of Uigur nationality and Han nationality. Methods： Data of 587 cases of H type hypertension inpatients in the fifth affiliated hospital of Subkiang medical university were collected from June 2011 to December 2012. Scope of data collection including nation, level of hypertension, serum Hcy. 305 cases of hypertension inpatients of Han nationality were collected, of which 176 cases were I level, 85 cases were II level, 44 cases were III level. 282 cases of hypertension inpatients of Uigur nationality were collected, of which157 cases were I level, 71 cases were II level, 54 cases were III level. Hcy level in serum were detected by HPLC, statistical analyses were performed respectively according to sexuality between Uigur and Han nationality, hypertension level. Results： Serum Hcy concentration of Uigur males （16.30 ± 9.97 μmol/L） was significantly higher than that of Han males （13.12 ± 7.43 μmol/L）（P〈0.05）. Serum Hcy concentration of Uigur females（14.91 ± 9.62 o, mol/L） was significantly higher than that of Han females （11.12± 8.43 μmol/L）（P〈0.05）. Serum Hcy concentration of I level hypertension patients of Uigur nationality （11.40± 5.97μmol/L） was equivalent to that of Han nationality （（11.36± 4.27 μmol/L）, serum Hey concentration oflI and III level hypertension patients of Uigur nationality （16.55± 6.69, 28.87± 9.12μmol/L） was significantly higher than that of Han nationality （14.45± 5.61, 22.36± 10.15 μmol/L）（P〈0.05）. Conclusion： there is some difference between serum Hcy concentration of type H hypertension patients of Uigur nationality and that of Han nationality, and serum Hcy concentration of Uigur nationality is higher than that of Han nationality.