摘要
进展期前列腺癌多会发生骨转移,导致患者骨质破坏甚至死亡。前列腺癌发生骨转移的机制目前尚未研究清楚。既往多认为是因为前列腺癌细胞表面携带者容易在骨环境中生长的表型。但是目前多认为是肿瘤细胞与骨骼微环境之间的相互作用导致的结果。它们之间是通过细胞因子来传递信息。在众多因子中,TGF-β对前列腺癌骨转移灶中的各种细胞都起着重要作用。研究表明在体外实验中TGF-β的作用极易受到细胞生长环境的影响,表现出不同的功能。这提示着TGF-β信号通路和其他信号通路之间存在非常强的交互作用。本文的重点在于对TGF-β在前列腺癌骨转移中的作用研究进展进行综述,阐述TGF-β对转移灶中不同细胞的作用,为今后肿瘤的治疗研究寻找一个好的方向。
Advanced-stage prostate cancers fi＇equently metastasize to the bones and cause bone destruction, even death, but the underlying mechanism is not fully understood. Early explanations for the preferential bone metastasis of prostate cancer are that prostate tumors have specific phenotypes that facilitate growth in the bone. However, recent studies have highlighted the importance of the bidirectional interactions between the bone microenvironment and the prostate cancer cells. They use cytokines to communicate with each other. In many factors, TGF-β plays an important role for different kind of cells in Prostate cancer bone metastases. Studies indicated that effects of TGF-β could be easily influenced by the microenvironment in which the cells were cultured. And this prompted that a very strong interaction exist between different signal pathways. In this review, we discussed the effects of TGF-β on different kinds of cell to get a better understanding of the complex tumor/microenvironment interplay and found a more effective therapies for patients with prostate cancer bone metastases.
出处
《现代生物医学进展》
CAS
2014年第24期4773-4775,4797,共4页
Progress in Modern Biomedicine
基金
兰州市科技发展计划重点支持项目(11-1-22)
