摘要
小分子核糖核酸(microRNA)是一类约20个核苷酸单链,在转录后水平调节基因的表达。microRNA广泛分布于人体各个组织器官内,但同时也有显著的组织特异性,不同的组织器官中miRNA的表达强度有显著差异,某些microRNAs在肾脏组织中呈特异性的高表达。肾间质纤维化是各种慢性肾脏病进展至终末期,最终导致器官功能丢失的共同的病理过程和特征。通过多年累积的研究表明,一些特定的microRNAs与肾间质纤维化的进程密切相关,在这个过程中体现出极其复杂的调控机制,发挥多方面的作用。近年来,随着对microRNA的研究进一步深入,本文就microRNAs在肾间质纤维化进程中的表达特点、作用靶点及相关调控机制的研究进展进行如下综述。
MicroRNAs （miRNAs） are a class of approximately 20-nucleotides single-stranded endogenous RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs are widely distributed in human tissues and organs, with significant tissue specificity. The intensity of the miRNA expression in different tissues and organs have significant differences, as some microRNAs in kidney tissue have specificity of high expression. Renal interstitial fibrosis is the common pathological changes when most kinds of chronic kidney diseases progressed to end stage renal failure. Accumulated through years of research has shown that some specific microRNAs are closely associated with the process of renal interstitial fibrosis, in this process reflects the very complicated regulatory mechanism, play a role in many aspects. While microRNA plays a key role via many mechanisems in this process. This paper reviews the progresses of mechainsms and targets of microRNA in renal interstitial fibrosis.
出处
《现代生物医学进展》
CAS
2014年第24期4794-4797,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81270776)
