中国肝细胞癌患者TACE术后死亡原因分析(英文)

Complications of Transcatheter Hepatic Arterial Chemoembolization(TACE) in Chinese Hepatocellular Carcinoma Patients Running Title: TACE-associated Mortality in China

目的:通过探讨中国肝细胞癌患者肝动脉化疗栓塞术(TACE)术后并发症及死亡原因,来提高临床治疗效果,并积累治疗经验。方法:通过联合检索CBM及CNKI上从1994年1月到2008年9月的关于中国肝细胞癌患者行TACE术后出现并发症的相关文章,分析总结肝细胞癌患者TACE术后死亡的原因及特点。结果:中国肝细胞癌患者TACE术后并发症较为危重,致死率较高,死亡原因有84%是肝功能衰竭、上消化道出血及肝癌破裂出血,且死亡病例发生在术后1月内的占78.7%,因此大多是早期死亡。结论:中国肝细胞患者TACE术后死亡原因主要是肝功能衰竭、上消化道出血及肝癌破裂出血,且术后死亡常为早期死亡,因此TACE术后严重并发症可直接影响患者的预后情况,我们需要提高对TACE术选择时机的重视程度,规范介入治疗手段和流程,尽量避免和减少严重并发症的发生。

Objective： To discuss the complications related to TACE in Chinese patients so as to increase the clinical effect and to gain more experience. Methods： We retrieved articles from January 1994 to September 2008 in Chinese Medical Current Content （CBM） and National Knowledge Infrastructure （CNKI）. Meta-analysis was performed on the results of homogeneous studies. All calculations for the current meta-analysis were performed using REVIEW MANAGER 4.2. Results： There were 150 reported cases of deaths after TACE, among which hepatic failure, upper gastrointestinal bleeding and ruptured liver cancer with hemorrhage occurred in 84% of cases, and 78.7% survived less than one month after operation. Conclusion： The primary etiology of death following TACE is acute liver failure, upper gastrointestinal bleeding and ruptured liver cancer with hemorrhage. The majority of peri-procedure fatalities are less than 30 days following TACE.