补中益气颗粒对产后盆底功能障碍患者盆底肌力及外周血TGF-β_1、IGF-1的影响

Effect of Buzhong Yiqi Granule on Pelvic Floor Muscle Strength and TGF- β_1,IGF-1 Contents in Peripheral Blood of Patients with Postpartum Pelvic Floor Dysfunction

目的:观察补中益气颗粒对产后盆底功能障碍患者盆底肌力以及外周血TGF-β1、IGF-1的影响。方法:将110例产后盆底功能障碍患者随机分为两组,对照组48例采取Kegel法锻炼;观察组52例在对照组的基础上加用补中益气颗粒,观察两组治疗前后盆底肌力及TGF-β1、IGF-1的变化。结果:观察组的盆底肌力、TGF-β1、IGF-1变化均优于对照组,差异有统计学意义(P<0.05)。结论:补中益气颗粒可提高产后盆底功能障碍患者的盆底肌力,其机理可能与影响TGF-β1、IGF-1合成与释放有关。

Objective：To observe the effect of Buzhong yiqi granule on pelvic floor muscle and TGF-β1,IGF-1 contents in peripheral blood of patients with postpartum pelvic floor dysfunction.Methods：110 cases with postpartum pelvic floor dysfunction were randomly divided into control group and treatment group.48 eases in control group received Kegel pelvic floor muscle exercises,52 cases in treatment group accepted Buzhong yiqi granules based on the treatment of control group.The pelvic floor muscle strength,TGF-β1,IGF-1 in peripheral blood in both groups were observed.Results：There were significant differences on pelvic floor muscle,TGF -β1,IGF-1 in peripheral blood between the two groups （P 〈 0.05）.Conclusion：Buzhong yiqi granule can improve the pelvic floor muscle strength of patients with postpartum pelvic floor dysfunction,its mechanism may be related to regulating the synthexsis and release of TGF-β1,IGF-1 in peripheral blood.