骨微环境内细胞因子对乳腺癌骨转移的影响

The effect of cytokines in the bone microenvironment on bone metastasis of breast cancer

骨是乳腺癌最常见且最优先的远部转移部位。乳腺癌细胞增殖转移到骨引起溶骨性和成骨性骨损伤,其发生是多个因素共同作用的结果,包括骨微环境提供的生长支持、乳腺癌细胞对骨微环境的适应能力,以及它们之间复杂的相互作用。骨微环境内细胞包括成骨细胞、破骨细胞、基质细胞、造血干细胞、内皮细胞等,这些细胞可产生多种细胞因子,促进乳腺癌细胞生长和乳腺癌骨转移进展;乳腺癌细胞也会释放多种因子,影响骨微环境内细胞及细胞因子,加重对骨的破坏。

Breast cancers preferentially metastasize to bone, which generally cause osteolytic and osteoblastic lesions. The crosstalk between metastatic breast cancer cells and bone microenvironment plays a central role in the development and pro-gression of bone metastases. Bone is rich in cell types and cytokine that make it a predominant environment for breast cancer cells growth. Once breast cancer cells enter the bone microenvironment,they can secrete factors that act on bone cells and contribute to the bone destruction.