原发性肝癌患者血清AFP、CEA、CA199水平变化的特异度、敏感度分析

The Changes of Serum AFP,CEA,CA199 Levels in Primary Liver Cancer

[目的]分析原发性肝癌患者血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)水平变化及联合检测的特异度和敏感度,为早期有效筛查肝癌提供方法。[方法]选取2012年1月至2013年6月期间我院收治的原发性肝癌患者64例为观察组,另选健康体检者64例作为对照组,观察两组受检者的血清AFP、CEA、CA199水平并进行比较分析。[结果]观察组的血清AFP、CEA、CA199水平明显高于对照组,两者比较差异均有统计学意义(P<0.05)。当2项或3项指标联合检测时,特异度有所下降,敏感度、准确性均有不同程度的升高(均P<0.05)。[结论]原发性肝癌患者血清AFP、CEA、CA199水平明显高于正常人,且均可在原发性肝癌中呈现阳性,联合检测3项指标能提高检测的敏感度和准确性,为早期有效筛查肿瘤提供了有效的方法。

[Objective]To investigate the clinical significance of serum AFP,CEA,CA199 levels in primary liver cancer.[Methods]64 patients with primary liver cancer were considered as the observation group from January 2012 to June 2013 in our hospital while 64 cases of healthy alternative were considered as the control group.The serum AFP,CEA,CA199 levels were analyzed and compared between the two groups.[Results]The serum AFP,CEA,CA199levels of the observation group were significantly higher than the control group,the difference was statistically significant（P〈0.05）.When two or three markers in the detection,the specificity decreased,sensitivity,accuracy increased in varying degrees.[Conclusion]The AFP,CEA,CA199 levels in primary liver cancer patients were significantly higher than normal,and it can be found in primary liver cancer,three indicators combined detection can improve the detection sensitivity and accuracy,to early and effective screening for the presence of tumor.