氟比洛芬酯靶向镇痛的临床研究

Study on flurbiprofen targeting analgesia

目的探讨氟比洛芬酯全身静脉用药与局部静脉用药靶向镇痛的效果。方法选取上肢手术成人患者,臂丛麻醉,上止血带的病人60例随机分为三组,A组上止血带后静脉远心端给氟比洛芬酯100 mg,B组上止血带前外周静脉给氟比洛芬酯100 mg,C组对照组静脉给脂肪乳剂10 mL。每组病人都在臂丛麻醉并且效果好后,手术开始之前给药,观察术中,术后1 h、4 h、8 h、12 h、24 h的VAS,止血带反应发生的例数,及其他不良反应。结果 A组与B组比较各时间点VAS比较无显著差异,止血带反应发生的时间与发生率无显著差异,A组,B组与C组比较VAS各时间点较低,止血带反应发生率低,比较有显著差异,其他不良反应发生率无差异。结论氟比洛芬酯无论全身静脉给药,还是局部静脉给药都有很好的靶向镇痛效果,且能延长止血带反应的时间,减少止血带反应的发生,无其他不良反应。

Objective To investigate the effect on flurbiprofen targeting analgesia given by systemic vein and local vein. Methods Sixty patients undergoing upper extremity surgery with tourniquet were randomly and equally allocated into three groups, group A （flurbiprofen 100 mg by local vein）, group B （flurbiprofen 100 mg by systemic vein） and group C （fatty emulsion）. After successful brachial plexus anesthesia,the flurbiprofen was given and visual analogue scale/score （VAS） was recorded at intraoperation, postoperative 1, 4, 8, 12, 24 hour. Meanwhile, tourniquet reaction and other side-effects were observed. Results VAS in the each time point, tourniquet reaction and other side-effects were compared between group A and group B, which showed no significant difference. VAS in the each time point and tourniquet reaction of the group A and B were lower than that of group C （P〈0.05）. Conclusion No matter what flurbiprofen is given by systemic or local vein, it has an excellent targeting analgesic results, and it would prolong time of tourniquet reaction and reduce tourniquet reaction and other side-effect.