布比卡因脂质体注射用悬浮液Exparel临床应用研究进展

Progress in clinical application of the bupivacaine liposome injectable suspension Exparel

长效酰胺类局麻药布比卡因常常用于术后镇痛,普通注射剂(浓度0.5%)产生不足7 h的镇痛作用,2011年美国食品药品监督管理局批准布比卡因脂质体注射用悬浮液Exparel上市,单剂量(浓度1.3%)直接注射产生长达72 h镇痛作用,这对于围手术期和术后镇痛控制是很重要的。本文就近年来布比卡因脂质体注射用悬浮液Exparel临床应用的研究进展作一综述。

Long-acting amide local anesthetic bupivacaine is often used for postsurgical analgesia.Ordinary injection（concentration of 0.5%） produces the analgesic effect less than 7 hours.In 2011,the U.S.Food and Drug Administration approved the bupivacaine liposome injectable suspension Exparel for marketing.A single injection of Exparel（concentration of 1.3%） produces postsurgical pain control up to 72 hours,which is very important to relieve perioperative and postsurgical pain.This paper focuses on the progress in clinical application of the bupivacaine liposome injectable suspension Exparel.