摘要
目的:分析克林霉素所致不良反应的特点,为临床合理应用提供参考。方法:对2007年1月至2012年12月北京市收到的2 121例克林霉素所致不良反应进行统计和分析。结果:2 121例克林霉素所致不良反应报告中,静脉滴注给药1 993例,占94.0%。不良反应表现居前3位的分别是皮肤损害、消化系统损害和全身症状。严重不良反应有39例。经逐年对比,克林霉素致不良反应例数呈逐年下降趋势。结论:合理使用克林霉素可以减少其不良反应的发生。建议除非病情需要,尽量使用克林霉素口服制剂,且在使用时对患者进行安全性监测,以降低风险。
Objective:To analyze the characteristics of adverse drug reaction(ADR) of clindamycin for providing a reference for clinically rational drug use.Methods:A total of 2 121 ADR reports associated with clindamycin collected from Beijing from 2007 to 2012 were analyzed.Results:Among the 2 121 ADRs,1993(94.0%) were induced by intravenous injection.The majority of reported ADRs were the damage of skin,gastrointestinal system and systemic symptoms.Among them,there were 39 serious ADRs.The number of clindamycin ADRs showed a downward trend from 2007 to 2012.Conclusion:It is necessary to strengthen rational use of clindamycin to reduce the occurrence of ADRs.If possible,oral preparation is suitable for the use of clindamycin unless the illness needs.Safety monitoring should be carried out on patients during application of clindamycin to reduce the risk of ADRs.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第14期1708-1711,1716,共5页
Chinese Journal of New Drugs
关键词
克林霉素
不良反应
分析
clindamycin
adverse drug reaction
analysis