丹参注射液联合低分子右旋糖酐等静脉补液治疗妊娠晚期羊水过少随机平行对照研究

Salvia Miltiorrhiza Combined Therapy with Low Molecular Dextran Oligohydramnios in Late Pregnancy Random Parallel Control Study

[目的]观察丹参注射液联合低分子右旋糖酐等静脉补液治疗妊娠晚期羊水过少疗效。[方法]使用随机平行对照方法,将70例住院患者按掷骰子法随机分为两组。对照组38例静脉补液:1000mL5%葡萄糖+500mL0.9%氯化钠+500mL林格氏液,1次/d,静滴。治疗组32例6mL丹参注射液+500mL 5%葡萄糖;500mL低分子右旋糖酐-40葡萄糖+500mL0.9%氯化钠+500mL林格氏液,1次/d,静滴。连续治疗7d为1疗程。观测临床症状、羊水指数(AFI)、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈27例,有效30例,无效2例,总有效率93.75%。对照组痊愈8例,有效22例,无效16例,总有效率57.89%。治疗组疗效优于对照组(P<0.01)。AFI两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]丹参注射液联合低分子右旋糖酐等静脉补液治疗妊娠晚期羊水过少效果显著,值得推广。

[ Objective ] To observe salvia mihiorrhiza combined therapy with low molecular dextran oligohydramnios in late pregnancy curative effect. [ Methods ] Using random parallel control method, 70 cases of hospitalized patients were randomly divided into two groups according to roll the dice method. Control group of 38 cases of 2000 ml intravenous rehydration ： 1000 ml of 5% glucose ＋ 500 ml of 0.9% sodium chloride ＋ 500 ml ringer＇s solution, 1 / d, slatic drops. Treatment group and 32 cases of 6 ml of salvia mihiorrhiza injection ＋ 500 ml of 5% glucose, 500 ml low molecular dextran 40 glucose ＋ 500 ml of 0.9% sodium chloride ＋ 500 ml ringer＇s solution, 1 / d, static drops. Continuous treatment of 7 d for 1 course of treatment. Observation of clinical symptoms, AFI, adverse reactions. As a course treatment,judge curative effect. [ Results ] the treatment group（ 27 cases cured, effective 30 eases, ineffective in 2 cases, total effective rate was 93.75%. Control group cure 8 cases, 22 cases effectively, 16 had no effect, the total effective rate was 57.89%. The treatment group curative effect is better than that of control group （ P〈0.01 ） . AFI two groups have improved （ P〈0.05 ）, the treatment group improved better than that of control group （ P〈0.05 ） . [ Conclusion ] Salvia miltiorrhiza combined low molecular dextran treatment of oligohydramnios in late pregnancy effect is remarkable, is worth promoting.