急性脑梗死合并OSAHS患者hs-CRP及Hcy水平的变化

The changes of hs-CRP and Hcy in patients with acute cerebral infarction (ACI) combines with Obstructive Sleep Apnea-hypopnea Syndrome (OSAHS)

目的探讨急性脑梗死(acute cerebral infarction,ACI)与睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)的关系。方法本研究分别采用乳胶增强免疫比浊法测定33例ACI、30例OSAHS以及32例ACI合并OSAHS以及同期的30例健康体检者患者的血清hs-CRP水平以及采用循环酶法检测血清Hcy水平,同时记录各组患者的睡眠呼吸暂停低通气指数(apnea-hypopnea index,AHI)。结果单纯ACI组、OSAHS组、ACI合并OSAHS组血清中hs-CRP以及Hcy水平明显高于正常对照组(均P<0.05);ACI合并OSAHS组血清中hs-CRP以及Hcy水平明显高于单纯ACI组(P<0.05),也明显高于OSAHS组(P<0.05);ACI组与OSAHS组血清中hs-CRP以及Hcy水平比较差异无统计学意义(P>0.05)。ACI合并OSAHS组中hs-CRP和Hcy水平随着AHI严重程度的增加而增加。结论 ACI组、OSAHS组、ACI合并OSAHS组和正常对照组均存在炎性反应和内皮功能损伤。ACI合并OSAHS组炎性反应和内皮功能损伤程度最高,两者均参与了动脉粥样硬化形成发展过程,二者联合可作为判断患者预后的重要检测指标。

Objective To investigate the relationship between acute cerebral infarction（ACI） and obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods The serum high-sensitivity C-reactive protein（hs-CRP） levels of 32 ACI assosiated OSAHS,33 ACI,30 OSAHS patients and 30 healthy subjects were measured by latex enhanced immunoturbidimetric assay. And the serum homocysteine（Hcy） was assayed by means of enzymatic cycling,while apnea-hypopnea index（AHI）was recorded. Results The serum levels of hs-CRP and Hcy in ACI,OSAHS and ACI associated OSAHS group were higher than those of the control group;the serum levels of hs-CRP and Hcy in ACI assosiated OSAHS were significantly higher than those of ACI,OSAHS and control group（ P〈0. 05）. Besides,the serum hs-CRP and Hcy levels were correlated positively with AHI. Conclusion OSAHS was likely to promote development and evolution of ACI by enhancing the way of inflammatory. Combination of hs-CRP and Hcy can be important indicator for the prognosis of ACI.