不同治疗方案治疗青春期功血82例临床分析

Clinical analysis of 82 cases on different therapy in puberty dysfunctional uterine bleeding

目的探讨中药和西药在治疗青春期功血临床中的疗效。方法根据纳入标准收治82例青春期功血患者,均未婚,依从性较好,无性生活史,年龄12～19岁,平均年龄16.2岁。阴道出血时间为5～70 d,平均40 d。Hb 65～100 g/L,经B超检查和血液检测,均无器质性和血液系统病变。依据随机对照原则,分为中药组和西药组2组,每组各41例,西药组口服补佳乐与黄体酮胶丸进行治疗;中药组口服左归丸治疗。30 d后观察疗效、不良反应、出血量纠正情况及随访6个月调经疗效。疗效、不良反应、出血量数据均采用SPSS 11.0统计软件进行分析,检测方法采用显著性检验、χ^2检验和t检验。结果西药组的控制出血时间是（33.8±11.8）h,完全止血时间是（56.2±22.7）h,中药组的控制出血时间是（60.5±15.6）h,完全止血时间是（76.4±23.6）h,西药组在控制出血时间和完全止血时间以及调经疗效上明显优于中药组,2组的疗效差异具有统计学意义（P〈0.05）;西药组不良反应发生率是14.63%,中药组不良反应是4.88%,西药组不良反应高于中药组,但差异不具有统计学意义（P〉0.05）。结论青春期功血的治疗,西药组疗效优于中药组。

Objective To study the effect of Chinese medicine and Western medicine in the treatment of the puberty dysfunctional uterine bleeding. Methods According to the rule of randomized control,82 patients were divided into 2 groups which were treated with Chinese medicine and Western medicine respectively,with 41 in each. The patients were all unmarried and had high compliance and no sexual relationships,with the average ages of 16. 2,ranging from 12 to 19. Their average bleeding time in vagina was 40 days,ranging from 5 to 70 days. Their HGB was changed from 65 g /L to 100 g /L.By the B-ultrasonography and blood test,they all had no organic and blood disease. The Western medicine group was treated with progynova and progesterone soft capsules;the Chinese medicine group was treated with left-restoring pill. Curative effects,adverse reaction,anemia-corrected and the control of hemorrhage were observed after 30 days. The effect of regulation menstruation was also followed up for 6 months. The data were analyzed by the software of SPSS 11. 0 with significance test,chi-square test and T-test. Results In Western medicine group,the control time of hemorrhage was（33. 8 ±11. 8）hours,the complete hemostatic time was（56. 2 ± 22. 7）hours;in Chinese medicine group,the control time of hemorrhage is（60. 5 ± 15. 6）hours,the complete hemostatic time is（76. 4 ± 23. 6）hours;the effect in Western medicine group was superior to Chinese medicine group in the control time of hemorrhage,the complete hemostatic time and the result of clinical healing;the difference of the effect between two groups had no statistical significance（ P〈0. 05）. However,the adverse reaction ratio with Western medicine group was 14. 63% and Chinese medicine group was 4. 88%;the adverse reaction with Western medicine group was higher than Chinese medicine group,but they had no significant difference（ P〉 0. 05）. Conclusion The Western medicine was better than Chinese medicine on the therapy for puberty dysfunctional uterine bleeding.