胶东半岛地区真菌性角膜炎临床特点

CLINICAL FEATURES OF FUNGAL KERATITIS IN JIAODONG PENINSULA

目的了解胶东半岛地区真菌性角膜炎流行病学及临床特点。方法对2009年1月—2013年12月就诊于我院的真菌性角膜炎病人282例临床资料进行回顾性分析。结果 282例病人中男176例（62.4%）,农民234例（83.0%）,发病的集中年龄为20～60岁。175例有角膜外伤史,其中植物外伤史占60.6%。真菌培养镰刀菌阳性率59.0%（92/156）,占首位。角膜清创、碘酊烧灼联合抗真菌药物治疗有效率42.6%,药物及手术治疗后最终眼球保存率95.7%。结论真菌性角膜炎多发于有角膜外伤的中老年男性农民,致病菌以镰刀菌为主,角膜清创联合抗菌药物治疗可控制早期病情,手术仍是治疗该病的主要手段。

Objective To study the epidemiological and clinical characteristics of fungal keratitis in Jiaodong peninsula.Methods A total of 282cases of fungal keratitis seen in our hospital-between January 2009and December 2013-were retrospectively reviewed. Results Of the patients reviewed,176patients（62.4%）were male,and 234（83.0%）farmers,age of onset mostly at 20—60.A history of cornea injury was noted in 175cases,of which,60.0% were caused by plants.A fungal cultivation showed Fusarium accounted the first place（59.0%）.The effective rate of corneal ulceration debridement and iodine ablation combined with antimycotic drug was 42.6%.The eye preservation rate after antimycotic drug and surgical treatment was 95.7%. Conclusion Fungal keratitis mostly occurs in middle-to-old aged male farmers,the pathogenic bacteria mainly being fusarium.Combined corneal debridement with antimycotic drug can control early lesions,and surgery is still a major means to treat the disease.