1型糖尿病病人骨密度的变化及其影响因素

BONE DENSITY AND ITS INFLUENCING FACTORS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

目的观察1型糖尿病病人骨密度(BMD)的变化及其影响因素。方法采用双能X线骨密度测量仪,测定108例1型糖尿病病人及106例非糖尿病人腰1(L1)~L4及左侧髋部(股骨颈、大转子、ward三角、股骨干及左髂骨总体)BMD,同时测定受试者年龄、身高、体质量、腰围、臀围、病程、糖化血红蛋白(HbA1c)等指标。结果两组各部位BMD比较,差异有显著性(t=-7.105^-3.022,P<0.01)。1型糖尿病病人L1~L4总体BMD和左髂骨总体BMD与年龄、HbA1c呈负相关(β=-0.410^-0.148,P<0.05),与BMI正相关(β=0.673、0.054,P<0.05);左髂骨总体BMD与性别有关(β=-0.208,P<0.05)。结论 1型糖尿病病人BMD低于对照人群,1型糖尿病病人的性别、年龄、BMI、HbA1c水平与BMD关系密切。

Objective To investigate the bone mineral density（BMD）and its influencing factors in type 1diabetic（T1DM）. Methods BMD at the lumbar spine（L1-L4）and femur（neck,ward triangle,trochiter,shaft of femur,left ilium）were measured in 108patients with T1DM and 106controls using dual-energy X-ray absorptiometry（DXA）.The age,height,body weight,waistline,hip circumference,course of disease,and glycosylated hemoglobin（HbA1c）were detected in all the subjects. Results The differences of BMD in each part detected between the two groups were significant（t=-7.105--3.022,P〈0.01）.In type 1diabetic patients,the BMD in L1-4total and left hip total were correlated with HbA1clevel and age（β=-0.410--0.148,P〈0.05）,and BMI（β=0.673,0.054;P〈0.05）.The BMD in left hip total was associated with gender（β=-0.208,P〈0.05）. Conclusion BMD in type 1diabetic patients was significantly lower than control subjects;which is closely related with the patient＇s,sex,age,BMI and HbA1c.