UCP2基因45I/D和A55V多态性与高加索人肥胖相关性Meta分析

THE CORRELATION BETWEEN 45I/D AND A55V POLYMORPHISMS IN UCP2 GENE AND OBESITY IN CAUCASIAN:A ME-TA-ANALYSIS

目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果进行统计分析。采用异质性检验和发表偏倚的评估来验证研究的可信性。用Meta分析探讨研究间潜在的异质性来源。结果共有11篇文献符合纳入标准，包括3936例肥胖者和4156例对照。敏感性分析后，Meta分析结果显示，45I／D多态性与肥胖关系的共显性模型合并OR为1．025（95％CI=0．879～1．195）、显性模型为0．998（95％CI=0．845～1．179）、隐性模型为1．169（95％CI=0．867～1．578），A55V则分别为0．976（95％CI=0．871～1．093）、0．964（95％CI=0．807～1．151）、0．972（95％CI=0．799～1．183）。结论UCP2基因45I／D和A55V多态性与高加索人肥胖可能不存在关联。

Objective To assess the relation of UCP2 45I/D and A55V polymorphisms with obesity susceptibility in Cau- casian. Methods PubMed, Science Direct Online, Springer Link, EBSCO and Google Scholar databases were searched for rele- vant studies. The results of the studies concerned were analyzed using Stata version 10.0. Heterogeneity and publication bias evalua- tion were performed to validate the credibility. Meta regression was used to explore the potential sources of between-study hetero geneity. Results A total of 11 articles including 3 936 obese cases and 4 156 non-obese controls-met the inclusive criteria. After sensitive analysis, the meta-analysis results showed that for 451/D, the pooled OR was 1.025 （95%CI=0.879--1.195） in eodomi- nant model, 0.998 （95%CI=0.845--1.179） in dominant model and 1.169 （95%CI=0.867--1.578） in recessive model. For A55V, the pooled OR was 0.976 （95%CI=0.871 1.093） in codominant model, 0.964 （95%CI=0.807 1.151） in dominant model and 0.972 （95%CI=0.799--1.183） in recessive model. Conclusion This recta-analysis indicates that there might be no association of UCP2 gene polymorphisms （45I/D and A55V） with obesity in Caucasian.