临床标本分离的鲍曼不动杆菌耐药性及其变迁

THE RESISTANCE AND VICISSITUDE OF Acinetobacter baumannii ISOLATED FROM CLINICAL SAMPLES

目的研究临床标本分离的鲍曼不动杆菌的耐药性及其变化,为临床合理使用抗菌药物提供依据。方法用细菌分离鉴定技术和药敏试验方法,对某医院临床科室送检病人标本进行细菌学检验与分析。结果该医院连续3年共检测临床送检病原学标本32 166份,检出病原菌12 805株;其中检出鲍曼不动杆菌1 574株,检出率为4.9%,占病原菌总数的12.3%。鲍曼不动杆菌感染主要分布在重症医学科、呼吸内科、急诊科、神经外科。临床分离的鲍曼不动杆菌对临床常用抗菌药物耐药率均超过60%,对亚胺培南的耐药率也超过60%。结论该医院临床送检标本中鲍曼不动杆菌分离率较高,呈现严重耐药,应加强耐药菌监测和抗菌药物使用管理。

Objective To investigate the drug resistance and vicissitude of Acinetobacter baumannii isolated from clinical samples and provide basis of rational use of antimicrobial drug for the clinical medicine. Methods Bacterial separating technology and susceptibility testing method were used to identify the patient specimens from clinical department of a hospital. Results 32 166 etiology samples from clinical department of this hospital were detected in three consecutive years, and 12 805 strains of pathogens were found. 1 574 strains of Acinetobacter baumannii were found in these specimens, the detection rate of samples was 4. 9% and which accounted for 12. 3% of the total number of pathogens. Acinetobacter baumannii was found mainly in Intensive Care Unit （ICU）, respiration department, emergency department and neurosurgery. The drug resistance rate of Acinetobacter baumannii isolated to commonly used antibiotics was over 60%, which was more than 60% to Imipenem. Conclusions The separating rate of Acinetobacter baumannii in this hospital was high, and it showed serious drug resistance. We should strengthen the resistant bacteria monitoring and management of antimicrobial drug.