硫糖铝联合黄连素治疗慢性顽固性胃炎临床疗效观察

Clinical Observation on Sucralfate Combined with Berberine in Treatment of Refractory Chronic Gastritis

目的:探讨硫糖铝和黄连素联合治疗慢性顽固性胃炎的临床效果。方法:选取156例慢性顽固性胃炎患者,随机均分为对照组和治疗组,对照组给予枸椽酸铋钾颗粒联合克拉霉素分散片治疗,治疗组给予硫糖铝联合黄连素治疗,观察两组患者的临床治疗效果、不良反应情况及治疗前后患者幽门螺旋杆菌检测的变化。同时对所有患者随访1年,观察复发情况。结果:治疗组患者总有效率、幽门螺旋杆菌转阴率、复发率均优于对照组,差异显著(P<0.05)。结论:硫糖铝联合黄连素治疗慢性顽固性胃炎具有良好的临床治疗效果,HP转阴率高,复发率低,值得临床推广。

Objective： To observe clinical effect of sucralfate combined with berberine in the treatment of refractory chronic gastritis.Methods： 156 Patients with chronic gastritis refractory were randomly selected and divided into control group and treatment group. The Control group was given bismuth potassium citrate and omeprazole, the treatment group was given sucralfate and berberine. The clinical effect, adverse reactions and level of HP were observed during the different stages of treatment. one-year follow-up observation was conducted to monitor relapses. Results： Compared with the control group, the treatment group recorded higher total efficiency, HP negative conversion ratio, and less relapses. Significant difference between the two groups was observed（P0.05）. Conclusion： Sucralfate combined with berberine in the treatment of refractory chronic gastritis has agreeable clinical effect, lower HP negative rate and less relapses. The treatment should be promoted and popularized in clinical use.