间苯三酚与黄体酮联合治疗先兆流产合并绒毛膜下血肿的临床分析

Clinical Analysis on Combination of Phloroglucinol-Progesterone for Treatment of Threatened Abortion with Subchorionic Hematoma

目的：探讨间苯三酚注射液和黄体酮注射液联合治疗因黄体功能不全致早期先兆流产合并绒毛膜下血肿的临床疗效。方法：将我院2011年1月~2014年1月门诊及住院部收治的80例黄体功能不全致先兆流产合并绒毛膜下血肿的患者随机分为研究组与对照组,对照组给予黄体酮注射液治疗,研究组在对照组基础上给予间苯三酚注射液治疗,比较两组患者的治疗效果、用药天数和药物不良反应,并进行统计学分析。结果：研究组患者的腹痛及阴道流血等临床症状得到较快的缓解,其用药天数减少,治疗效果更好,患者不良反应较少,与对照组比较,P〈0.05,差异有统计学意义。结论：间苯三酚联合黄体酮治疗黄体功能不全致早期先兆流产合并绒毛膜下血肿可取得较好的效果,提高保胎成功率,且不良反应降低,值得临床推广应用。

Objective： To explore the clinical curative effects of combination of phloroglucinol injection and progesterone injection for treatment of luteal-phase-defect-induced threatened abortion with subchorionic hematoma. Methods： From January 2011 to January2014, 80 Patients with luteal-phase-defect-induced threatened abortion and subchorionic hematoma, were randomly divided into two groups in our hospital, control group and research group. Patients in control group were given progesterone injection and patients in research group were applied to progesterone injection combined with phloroglucinol. After several days, the clinical efficacy and adverse drug reaction of patients in two groups were compared and analyzed. Results： Compared with control group, clinical symptoms of patients in research group, such as abdominal pain and colporrhagia, were alleviated sooner. Moreover, the period of taking medicine shortened,better results achieved and the adverse drug reaction reduced. Statistically significant differences between the two groups were observed（P0.05）. Conclusion： Combination of phloroglucinol injection and progesterone injection for treatment of luteal-phase-defect-induced threatened abortion with subchorionic hematoma can achieve better therapeutic effect, contribute to the success of tocolysis, and reduce adverse drug reaction. The treatment is worth being popularized in clinical use.