津力达联合格华止改善2型糖尿病患者胰岛功能40例

Tianjin Lida Particles and Glucophage Improve Islet Function in Type 2 Diabetic Patients

目的观察津力达颗粒联合格华止治疗气阴两虚型2型糖尿病的疗效及安全性。方法将80例2型糖尿病患者随机分为格华止+津力达组40例和格华止组40例,格华止+津力达组采用津力达颗粒联合格华止治疗中医辨证为气阴两虚证的2型糖尿病,格华止组给予格华止2.5mg,每日1次口服,观察两组治疗前后空腹血糖、餐后血糖、胰岛功能变化及代谢紊乱症状群改善情况。结果两组治疗后FPG、2hPG、HbA1c较治疗前均有显著下降(P<0.01),格华止+津力达组血糖达标的时间,格华止每日用量、低血糖发生率均低于格华止组,且格华止+津力达组口渴多饮、自汗、盗汗、倦怠乏力等症状改善好于格华止组,两组比较有显著性差异(P<0.05)。两组均未发现明显毒副作用,治疗前后身体质量变化不大。结论津力达颗粒联合格华止治疗气阴两虚证的2型糖尿病,比单用格华止更有效,且安全性好。

Objective To observe the Tianjin joint force of particles Glucophage Qiyinliangxu efficacy and safety of treatment of type 2 diabetes.Methods 80 patients with type 2 diabetes were randomly divided into a treatment group of 40 patients and the control group 4O cases,the treatment group of particles using Jinli joint Glucophage TCM for the treatment of type 2 diabetes Qi Deficiency,the control group received Glucophage1mg,1 times a day orally,observed blood glucose control before and after treatment,islet function changes and improvement of symptoms. Results After treatment,FPG,2hPG,HbA1c compared with before treatment were significantly lower（ P〈0. 01）,blood glucose treatment group time,Glucophage daily dosage of hypoglycemia were lower than the control group,and the treatment group thirsty to drink,spontaneous improvement of symptoms,night sweats,fatigue and other than the control group,there were significant differences between the two groups（ P〈 0. 05）. The two groups were not found significant side effects,quality of care before and after the body is not. Conclusion Tianjin Lida particles combined treatment Glucophage Qi and Yin deficiency type 2 diabetes,more effective than single Glucophage and safety.