西安市体检人群高尿酸血症患病率及相关危险因素分析

Analysis of Prevalence and Associated Risk Factors of Hyperuricemia in Subjects Undergoing Routine Physical Examinations in Xi＇an

目的 探讨西安市体检人群中高尿酸血症（HUA）患病率及相关危险因素.方法 以5 380名体检人员为研究对象,其中男性2 731人,女性2 649人.分为三组：＜45岁为青年组,45-59岁为中年组,≥60岁为老年组.体检内容包括：身高、体质量、血压、心率、血常规、生化指标等,并计算体重指数（BMI）.应用SPSS17.0软件包进行统计分析,两组间计量资料均值比较用t检验,计数资料比较采用χ^2检验,危险因素采用二分类非条件logistic回归分析.结果 HUA患病率为12.7％,其中男性为18.0％,女性为7.3％.HUA组患者的年龄,BMI,SBP,DBP,FBG,TC,TG,LDL-C水平均高于非HUA组,HDL-C低于非HUA组,两组比较差异有统计学意义（t=3.582-16.879,P值均＜0.01）.青、中年组男性HUA患病率（20.8％,15.2％）明显高于同年龄组女性患病率（2.3％,6.8％）,差异有统计学意义（χ^2值分别为209.076,28.108,P值均为0.000）.而老年组女性HUA患病率（19.3％）高于同年龄组男性患病率（15.3％）,但差异无统计学意义（χ^2=3.284,P=0.070）.老年组总的HUA患病率（17.2％）高于中、青年组（10.8％,12.0％）,差异有统计学意义（χ^2值分别为23.536,18.000,P值均为0.000）.logistic回归分析显示,男性、年龄、BMI、高血压、高TG血症及LDL-C与HUA呈正相关,而高FBG及HDL-C与HUA呈负相关关系.结论 西安市体检人群HUA患病率为12.7％,男性、年龄、BMI、高血压、高TG血症及LDL-C是HUA的独立危险因素,而高FBG及HDL-C是HUA的保护因素.

Objective To investigate the prevalence and associated risk factors of hyperuricemia in subjects undergoing routine physical examinations in Xi＇an.Methods This study was conducted amony 5 380 subjects（2 731 male and 2 649 female） undergoing routine physical examinations.The subjects were divided into three groups,youth group was less than 45 years,middle-aged group was 45 -5 9 years old,older group was more than 60 （including 60） years.For all the subjects,such indices as body height,weight,blood pressure,heart rate and blood biochemistry were examined,and the body mass index （BMI） were calculated.t-test and chi-square test were separately used to evaluated the difference of measurement data and count data between two groups.The risk factors of hyperuricemia were analyzed using binary logistic regression analysis.Results The incidence rates of hyperuricemia were 12.7%,18.0% and 7.3% in male and female respectively.Age,BMI,systolic blood pressure,diastolic blood pressure,fasting blood glucose,total cholesterol,triglyceride and low density lipoprotein-cholesterol （LDL-C） were higher in HUA population than in non-HUA population,while high density lipoprotein-cholesterol （HDL-C） was opposite （t 3.582-16.879,P〈0.01）.The incidence of hyperuricemia of male in youth group （20.8%） and middle-aged group （15.2%） were higher than female in the same age groups （2.3%,6.8%,χ^2 209.076 or 28.108,P〈 0.01）.The incidence of hyperuricemia in older group （17.2%） was higher than middle-aged group （10.8%） and youth group （12.0%,χ^2 =23.536 or 18.000,P〈0.01）.Logistic regression analysis showed that gender （male）,age,BMI,hypertension status,hyperlipidemia and LDL-C were positively correlated with the incidence of hyperuricmia,while high fasting glucose and HDL-C were negatively correlated with the disease.Conclusion The incidence rate of hyperuricemia in subjects undergoing routine physical examinations in Xi＇an was 12.7%.The risk factors of hyperuricemia include gender （male）,age,elevation of BMI,hypertension status,hyperlipidemia and LDL-C,high fasting glucose and HDL-C can be protective factors against hyperuricemia.