PD-1/PD-L1通路在免疫调节作用中的研究进展

Research Progress of PD-1/PD-L1 in the Immune Regulation

程序性死亡分子1（programmed death-1,PD-1）与其配体PD-L（PD-L1,PD-L2）属于抑制性共刺激分子,PD-1及其配体PD-L1这一信号通路能对免疫反应的产生起负调节作用,因此,PD-1/PD-L1通路可能与感染性疾病慢性化和肿瘤细胞免疫逃避有关.该文就PD-1/PD-L1的分子结构、表达,在肿瘤免疫、细菌、病毒和寄生虫感染等疾病发生发展过程中的作用机理进行综述.

Programmed death-1 （PD-1） and its ligand PD-L（PD-L1,PD-L2）,a kind of inhibitory costimulatory molecules,can play a role of negatively regulating immune responses.Therefore,PD-1/PD-L1 pathway may be associated with chronic progression of infectious diseases and immune response evasion of tumor cells.This paper reviews the molecular structure and expression of PD-1/PD-L1,and its mechanism of the development process in tumor immunity,bacterial,viral and parasitic infections and other diseases.