CRP对输血不良反应的预测价值分析

Value of C-reactive Protein to Diagnosis of Blood Transfusion Reactions

目的 了解C反应蛋白（CRP）测定对输血不良反应的预测价值,为输血不良反应的预防和干预提供参考依据.方法 采用免疫荧光法测定129例输血患者输血前后的全血CRP水平.以发生发热反应的32例输血患者作为发热反应组、发生过敏反应的46例输血患者作为过敏反应组、无输血不良反应的51例输血患者作为正常对照组.结果 输血后发热反应组和过敏反应组CRP分别为27.9±10.7 mg/L和16.7±9.3 mg/L,高于输血前的12.7±9.6 mg/L和10.0±6.3mg/L,与正常对照组比较,t发热=3.238,P发热＜0.05;t过敏=5.041,P过敏＜0.05,差异均有统计学意义;两输血不良反应组输血前后CRP比较,t=2.568,P＜0.05,差异有统计学意义.结论 CRP是炎症标志物,输血不良反应发生时CRP显著升高,CRP测定对输血不良反应的诊断有一定应用价值.

Objective To understand the predictive value of C reactive protein（CRP） for transfusion adverse reactions,and to provide theoretical reference basis for prevention and intervention blood transfusion reactions.Methods 32 cases of blood transfusion patients with fever adverse reaction were choosed as fever reaction group,46 patients with allergic as allergic reaction group,51 cases of blood transfusion patients without adverse reactions as control group between June 2012 and October 2013 in Baixiang People＇s Hospital of Hebei.CRP levels in the whole blood were determined by using immunofluorescence method before and after blood transfusion.Results CRP （27.9-10.7,16.7-9.3） mg/L levels after blood transfusion in fever reaction and allergic reaction group were higher than those （12.7± 9.6,10.0± 6.3） mg/L before blood transfusion,compared with normal control group respectively,the differences were statistically significant （P＜0.05）.CRP levels after blood transfusion in two blood transfusion reactions groups were compared,CRP levels in fever reaction group was higher,the difference was statistically significant （P＜0.05）.Conclusion CRP is inflammatory markers,CRP level revealed a significant rise in blood transfusion reactions,determination of CRP has certain application value to the diagnosis of blood transfusion reactions.