冰片-安息香配伍对苯甲酸、肉桂酸药代动力学的影响

Influence of Benzoinum and Borneolum Syntheticum on Pharmacokinetics of Benzoic Acid and Cinnamic Acid in Rats

目的：探讨安息香与冰片配伍对安息香主要成分苯甲酸、肉桂酸药代动力学的影响.方法：SD大鼠随机分为两组,分别灌胃给予单味安息香及安息香-冰片配伍药液,采集不同时间点的血浆样品,分别测定血浆中苯甲酸及肉桂酸的含量,并计算其药代动力学参数.结果：给予单味安息香和安息香-冰片配伍药液的Tmax分别为苯甲酸（1.57±1.99）,（11.42±3.78） min,肉桂酸（32.86±3.13）,（11.71±2.96） min;Cmax分别为苯甲酸（34.93±11.65）,（40.35±22.72） mg·L-1,肉桂酸（2.96±1.10）,（3.43±1.38） mg·L-1;AUC（0～∞）分别为苯甲酸（4 481.42±879.21）,（3 942.21±977.52） min· μg-1·mL-1,肉桂酸（601.16±45.84）,（401.33±23.35） min·μg-1·mL-1.结论：安息香与冰片配伍,苯甲酸和肉桂酸的Tmax显著减小,提示二药配伍能加快苯甲酸和肉桂酸在大鼠体内的吸收速度.

Objective：To study the pharmacokinetics of benzoic acid and cinnamic acid in rats plasma after oral administration of Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum.Method：SD rats were divided into two groups randomly,giving Benzoinum liquid or the mixing liquid of Benzoinum and Borneolum Syntheticum respectively,collecting the plasma samples at different time.Then determining benzoic acid and cinnamic acid contents,and calculating the pharmacokinetic parameters.Result：The experiments showed the Tmax were （41.57 ± 1.99）,（11.42 ±3.78） min for benzoic acid,（32.86 ±3.13）,（11.71 ± 2.96） min for cinnamic acid.The maximum plasma concentration （Cmax） were （34.93 ± 11.65）,（40.35 ±22.72） mg ·L-1 for benzoic acid,（2.96 ± 1.10）,（3.43 ± 1.38） mg ·L-1for cinnamic acid.The AUC（0～∞） were （4 481.42 ±879.21）,（3 942.21 ±977.52） min ·μg-1·mL-1 for benzoic acid （601.16 ±45.84）,（401.33 ±23.35） min ·μg-1·mL-1 for cinnamic acid.Conclusion：In the compatibility of Benzoinum with Borneolum Syntheticum the Tmax of benzoic acid and cinnamic acid were significantly reduced,suggesting that the compatibility of the two drugs can accelerate the absorption speed of benzoic and cinnamic acid in rats.