基于数据挖掘对治疗脾虚型胃气上逆病证用药规律的研究

Analysis on Composition Principles of Prescriptions for Complex Symptoms of Adverse Rising of Gastric Qi of Deficiency of Spleen Based on Data Mining

目的:研究《中医方剂大辞典》中治疗脾虚型胃气上逆病证方剂的组方用药规律。方法:应用中医传承辅助系统(V1.3),收集、整理治疗脾虚型噎嗝、呃逆、嗳气、干呕、呕吐、反胃的方剂,录入系统并利用熵方法与apriori算法进行组方规律分析。结果:对筛选出的1 452首方剂、934味中药进行分析,使用频次在50次以上的药物有45味;基于apriori算法分析组方规律得出:使用频次在100次以上的29个常用药对(支持度个数≤20),使用频次在60次以上的34个药物组合(支持度个数≤20),及药物关联规则分析,支持度个数≤20,置信度≤0.9;基于熵方法层次聚类的新处方分析得出:用于新方聚类的核心药物组合24对,以及24个候选新处方;以四君子汤的药物组成进行方剂匹配,相似度阈值为0.5,得出12首匹配方剂。结论:治疗脾虚型胃气上逆病证组方多以健脾益气为主,和胃降逆为辅,体现了异病同治的辨治理念。

Objective：To analyze composition principles of the prescriptions in the book of 〈 The Prescription of Traditional Chinese Medicine （TCM） Dictionary 〉 for the treatment of complex symptoms of adverse rising of gastric Qi of deficiency of spleen.Method：The prescriptions for complex symptoms of adverse rising of gastric qi of deficiency of spleen were collected,sorted and entered into the TCM inheritance system （V1.3） to analyze the composition principles by the methods of entropy and apriori.Result：Based on the analysis of 1 452 cases of prescriptions which have 934 medications,there were 45 medications with more than 50 frequencies are mined from the database.Composition principles were obtained with apriori method：there were 29 frequently used herbal pair with more than 100 frequencies （support≤20）,34 core combinations with more than 60 frequencies （support ≤ 20）.The association principles for those medications in the prescriptions were analyzed （support≤20,confidence≤0.9）.Principles were obtained with entropy：there were 29 core combinations which would compose the new prescriptions,and 29 new prescriptions were found by hierarchical clustering method.There were 12 prescriptions matching with Sijunzi tang （semblance =0.5）.Conclusion：We should chose strengthening spleen and benefiting vital medications primarily,assisting with regulating stomach and calming the adverse-rising gastric Qi,to treat the complex symptoms of adverse rising of gastric Qi of deficiency of spleen.