辛伐他汀治疗冠心病心绞痛急性发作期效果研究

Effects of acute exacerbation of angina pectoris treated with simvastatin

目的探讨对冠心病心绞痛急性发作期患者开展辛伐他汀治疗的临床效果以及对TC、TG的影响。方法选取2013年2月—2014年2月收治的冠心病心绞痛急性发作期患者98例,随机分为对照组与观察组各49例,两组患者均开展临床常规治疗,观察组患者增加辛伐他汀药物。观察两组患者治疗前后的心绞痛持续时间与发作次数,并通过全自动分析仪检测TC、TG、HDL-C、LDL-C。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后观察组发作情况好于对照组,差异均有统计学意义(均P<0.05)。治疗后观察组患者的TC、TG、HDL-C、LDL-C均显著好于对照组,差异均有统计学意义(均P<0.05)。对照组总有效率为79.6%,观察组为93.9%,观察组显著好于对照组,差异有统计学意义(P<0.05)。结论对冠心病心绞痛急性发作期患者应用辛伐他汀,可显著缓解心绞痛的发作情况,并且对TC、TG有显著的改善效果,值得进一步推广应用。

Objective To investigate the clinical efficacy of acute exacerbation of angina pectoris treated with simvastatin and its effects on the level of TC and TG. Methods 98 cases of acute exacerbation of angina pectoris treated in our hospi- tal from February 2013 to February 2014 were selected and randomly divided into control group and observer group, 49 ca- ses for each group. Conventional treatment was given to both groups. Simvastatin was given to observation group in addi- tion. Both groups were observed for the duration and frequency of angina attacks before and after treatment, as well as the level of TC,TG, HDL -C and LDL -C. Measurement data were processed by t test, count data byx2 test, the result of P 〈 0.05 was considered statistically significant. Results After treatment observation group was better than control group in disease attack, showing statistically significant difference （P 〈 0.05 ）. The level of TC ,TG, HDL- C and LDL- C was sig- nificantly improved in observation group than in control group, showing statistically significant difference （ P 〈 0.05 ）. The total effective rate was 79.6% in control group and 93.9% in observation group, observation group was superior to the con- trols, showing statistically significant difference （ P 〈 0.05 ）. Conclusions Simvastatin should be given to patients with a- cute exacerbation of angina pectoris, for it can significantly alleviate the condition and has obvious effects on the level of TC and TG has significant improving effect. Therefore, it deserves further application.