肥胖与重度反流性食管炎相关性的病例对照研究

The relationship between obesity and severe reflux esophagitis:a case-control study

[目的]探讨肥胖与重度反流性食管炎（RE）的相关性.[方法]采用配对病例对照研究方法,以新疆自治区人民医院消化内科2011年1月～2012年12月经胃镜明确诊断的重度RE患者124例为病例组,同期胃镜检查正常或轻度慢性浅表性胃炎124例为对照组.以体质指数（BMI）、腰围（WC）和腰臀比（WHR）作为肥胖检测指标,用多变量回归分析重度RE的危险因素.[结果]病例组BMI、WC及WHR均值均大于对照组（P＜0.001）.校正BMI、WC及WHR进行多变量Logistic回归分析发现重度RE发生与腰臀比有明显相关性（P=0.001,OR=4.578,95％CI：1.875～11.174）.[结论]增加腰臀比可能增加重度RE发生率.

[Objective]To identify the relationship between obesity and severe reflux esophagitis.[Methods]A case-control study was designed containing 124 cases as model group with severe reflux esophagitis diagnosed by endoscopy and 124 cases as control group with slight chronic superficial gastritis or completely normal during simultaneous observation.Obesity was detected through indexes including body mass index（BMI）,waist circumference （WC） and waist-hip ratio （WHR）.Multivariable logistic regression analysis was used to identify the independent risk factors associated with the presence of reflux esophagitis.[Results]Severe reflux esophagitis cases showed higher mean BMI,WC and WHR than those in controls（P＜ 0.001）.Correcting indexes of BMI,WC and WHR and multivariate Logistic regression analysis demonstrated that there was a significant correlation between severe reflux esophagitis and waist hip ratio（P=0.001,OR =4.578,95 ％ CI：1.875～ 11.174）.[Conclusion] High W H R was associated with increased incidence rate of severe reflux esophagitis.